603101-22-0

• 常用中文名：GNF-1331
• 常用英文名：GNF-1331
• CAS号：603101-22-0
• 分子式：C₂₀H₂₀N₆O₂S₂
• 分子量：440.542
• 发布时间：2021-01-10 19:22:27
• 更新时间：2023-12-12 07:29:38
• GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.

名称

• 英文名: gnf-1331
• 英文别名: MFCD03750964; Acetamide, N-(6-methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-; gnf-1331; N-(6-Methoxy-1,3-benzothiazol-2-yl)-2-{[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide; N-(6-Methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetamide

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₀H₂₀N₆O₂S₂
• 分子量: 440.542
• 精确质量: 440.108917
• LogP: 4.35
• 折射率: 1.724