氨己烯酸

更新时间:2024-01-08 19:32:09

氨己烯酸结构式
氨己烯酸结构式
品牌特惠专场
常用名 氨己烯酸 英文名 Vigabatrin
CAS号 60643-86-9 分子量 129.157
密度 1.1±0.1 g/cm3 沸点 277.7±28.0 °C at 760 mmHg
分子式 C6H11NO2 熔点 N/A
MSDS N/A 闪点 121.7±24.0 °C
符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger

 氨己烯酸用途


Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). It is a structural analog of GABA, but does not bind to GABA receptors. Vigabatrin is an irreversible suicide inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA, which increases the level of GABA in the brain. Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active.

 氨己烯酸名称

中文名 氨己烯酸
英文名 vigabatrin
中文别名 氨乙烯酸 | 4-氨基-5-己烯酸
英文别名 更多

 氨己烯酸物理化学性质

密度 1.1±0.1 g/cm3
沸点 277.7±28.0 °C at 760 mmHg
分子式 C6H11NO2
分子量 129.157
闪点 121.7±24.0 °C
精确质量 129.078979
PSA 63.32000
LogP -0.10
蒸汽压 0.0±1.2 mmHg at 25°C
折射率 1.483
储存条件 Desiccate at +4°C
分子结构

1、 摩尔折射率:34.62

2、 摩尔体积(cm3/mol):121.3

3、 等张比容(90.2K):308.0

4、 表面张力(dyne/cm):41.5

5、 极化率(10-24cm3):13.72

计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:2

3.氢键受体数量:3

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积63.3

7.重原子数量:9

8.表面电荷:0

9.复杂度:112

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1.性状:从乙醇-水结晶。

2.熔点:209℃。

3.溶解度:易溶于水。

 氨己烯酸毒性和生态

氨己烯酸毒理学数据:

急性毒性LD50。小鼠(mg/kg):>2500腹腔注射。

氨己烯酸毒性英文版

 氨己烯酸安全信息

符号 GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
信号词 Danger
危害声明 H225-H301 + H311 + H331-H370
警示性声明 P210-P260-P280-P301 + P310-P311
危害码 (欧洲) Xi
风险声明 (欧洲) R36/37/38
安全声明 (欧洲) S26-S36
危险品运输编码 MP7745000
WGK德国 2
RTECS号 MP7745000
海关编码 2922499990

 氨己烯酸制备

5-乙烯基-2-吡咯烷酮(I)和氢氧化钾,在含水异丙醇中进行水解反应,得到氨己烯酸,收率87%。60643-86-9 preparation

 氨己烯酸海关

海关编码 2922499990
中文概述 2922499990 其他氨基酸及其酯及它们的盐(含有一种以上含氧基的除外). 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件 A.入境货物通关单 B.出境货物通关单
检验检疫 P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 氨己烯酸文献51

更多文献
A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.

JAMA Psychiatry 70(6) , 630-7, (2013)

Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown...

Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function.

Brain. Behav. Immun. 27(1) , 80-90, (2013)

Our previous work has shown that the cerebellar fastigial nucleus (FN) is involved in modulation of lymphocyte function. Herein, we investigated effect of FN γ-aminobutyric acid (GABA)-ergic projectio...

Vigabatrin versus carbamazepine monotherapy for epilepsy.

Cochrane Database Syst. Rev. 1 , CD008781, (2012)

The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual fiel...

 氨己烯酸英文别名

vigabatrinum
4-Aminohex-5-enoic acid
Sabril
EINECS 200-659-6
4-Amino-5-hexenoic acid
UNII:GR120KRT6K
vigabatrinum [INN_la]
vigabatrine
MFCD00274577
Vigabatrin
vigabatrina
(±)-Vigabatrin
5-Hexenoic acid, 4-amino-
品牌现货直购
推荐供应商:



查看所有供应商和价格请点击:

氨己烯酸生产厂家

氨己烯酸价格