還原亞甲藍

• 常用名: 還原亞甲藍
• 英文名: TRX-0237
• CAS号: 613-11-6
• 分子量: 285.40700
• 密度: 1.201g/cm3
• 沸点: 491.7ºC at 760 mmHg
• 分子式: C₁₆H₁₉N₃S
• 熔点: N/A
• 闪点: 251.2ºC

還原亞甲藍用途

TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

還原亞甲藍名称

• 中文名: 還原亞甲藍
• 英文名: 3-N,3-N,7-N,7-N-tetramethyl-10H-phenothiazine-3,7-diamine

還原亞甲藍物理化学性质

• 密度: 1.201g/cm3
• 沸点: 491.7ºC at 760 mmHg
• 分子式: C₁₆H₁₉N₃S
• 分子量: 285.40700
• 闪点: 251.2ºC
• 精确质量: 285.13000
• PSA: 43.81000
• LogP: 4.16480
• InChIKey: QTWZICCBKBYHDM-UHFFFAOYSA-N
• SMILES: CN(C)c1ccc2c(c1)Sc1cc(N(C)C)ccc1N2
• 折射率: 1.675

還原亞甲藍靶点实验

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实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1023579

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Inhibition of congo red-induced EGFP-tagged Tau P301L mutant (unknown origin) aggrega... 来源：ChEMBL 靶标：Microtubule-associated protein tau External Id：CHEMBL4236009

实验名称：Protection against amyloid beta oligomer-induced cytotoxicity in human SH-SY5Y cells ... 来源：ChEMBL 靶标：SH-SY5Y External Id：CHEMBL4669397

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還原亞甲藍英文别名

• leucoform
• Reduced methylene blue
• N,N,N',N'-Tetramethyl-10H-phenothiazine-3,7-diamine
• Panatone
• Leukomethylene blue
• N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-diamine
• methylene white
• 2w9i
• Leucomethylene blue