Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl

• 常用名: Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl
• 英文名: Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl
• CAS号: 61369-43-5
• 分子量: 348.36
• 密度: 1.36g/cm3
• 沸点: 508.8ºC at 760 mmHg
• 分子式: C₁₉H₁₆N₄O₃
• 熔点: N/A
• 闪点: 261.5ºC

用途

NSC 288387是一种泛黄病毒MTase抑制剂。NSC 288387与SAM结合口袋结合。NSC 288387以0.2μM的IC50抑制ZIKV。NSC 288387还抑制细胞培养中的病毒复制[1]。

名称

• 英文名: 10-(2-methoxyethyl)-3-phenylbenzo[g]pteridine-2,4-dione

生物活性

• 描述: NSC 288387是一种泛黄病毒MTase抑制剂。NSC 288387与SAM结合口袋结合。NSC 288387以0.2μM的IC50抑制ZIKV。NSC 288387还抑制细胞培养中的病毒复制[1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9(7):1319-1333.

物理化学性质

• 密度: 1.36g/cm3
• 沸点: 508.8ºC at 760 mmHg
• 分子式: C₁₉H₁₆N₄O₃
• 分子量: 348.36
• 闪点: 261.5ºC
• 精确质量: 348.12200
• PSA: 79.01000
• LogP: 1.74200
• InChIKey: VBIVGEJXWFOZBG-UHFFFAOYSA-N
• SMILES: COCCn1c2nc(=O)n(-c3ccccc3)c(=O)c-2nc2ccccc21
• 折射率: 1.682

靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of YAP1 in human A549 cells assessed as disruption in YAP1/OCT4 co-localiz... 来源：ChEMBL 靶标：Transcriptional coactivator YAP1 External Id：CHEMBL4419939

实验名称：Inhibition of YAP1 in human NCI-H1650 cells assessed as disruption in YAP1/OCT4 inter... 来源：ChEMBL 靶标：Transcriptional coactivator YAP1 External Id：CHEMBL4419940

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibition of YAP1 in human NCI-H1650 cells assessed as disruption in YAP1/TEAD2 inte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4419941

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Identifying Sarm1 TIR NADase inhibitors through high throughput HPLC assay 来源：24386 靶标：N/A External Id：Sarm1 TIR NADase inhibitors

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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