2'-NH2-ATP

• 常用名: 2'-NH2-ATP
• 英文名: 2'-NH2-ATP
• CAS号: 61468-88-0
• 分子量: 506.20
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₇N₆O₁₂P₃
• 熔点: N/A
• 闪点: N/A

2'-NH2-ATP用途

2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate),一种腺苷衍生物,是 ATP 的弱竞争性抑制剂,Ki 值为 2.3 mM。2'-NH2-ATP 可用于核酸标记。

2'-NH2-ATP名称

• 英文名: 2'-NH2-ATP

2'-NH2-ATP生物活性

• 描述: 2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate),一种腺苷衍生物,是 ATP 的弱竞争性抑制剂,Ki 值为 2.3 mM。2'-NH2-ATP 可用于核酸标记。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体外研究: 2'-NH2-ATP(2 mM)不能取代ATP作为CTP合酶催化的NH3依赖性胞苷5'-三磷酸(CTP)形成的底物[2]。
• 参考文献:

  [1]. Armstrong VW, et, al. Interaction of substrate analogues with Escherichia coli DNA-dependent RNA polymerase. Eur J Biochem. 1976 Nov 1;70(1):33-8.

  [2]. Faylene A. L. KINETIC STUDIES ON WILD-TYPE AND MUTANT ESCHERICHIA COLICYTIDINE 5'-TRIPHOSPHATE SYNTHASES AND INHIBITOR DEVELOPMENT. Dalhousie University Halifax, Nova Scotia. 2008 Jul.

  [3]. Aström H, et, al. Acidity of secondary hydroxyls in ATP and adenosine analogues and the question of a 2',3'-hydrogen bond in ribonucleosides. J Am Chem Soc. 2004 Nov 17;126(45):14710-1.

2'-NH2-ATP物理化学性质

• 分子式: C₁₀H₁₇N₆O₁₂P₃
• 分子量: 506.20
• InChIKey: ROOXBFCHOCQAKL-RBLJNHJVSA-J
• SMILES: Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])C(O)C1N.[Na+].[Na+].[Na+].[Na+]

2'-NH2-ATP靶点实验

查看更多实验

实验名称：Substrate activity at recombinant full-length chicken CGAS expressed in Escherichia c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4338394

实验名称：Substrate activity at recombinant full-length mouse CGAS expressed in Escherichia col... 来源：ChEMBL 靶标：Cyclic GMP-AMP synthase External Id：CHEMBL4338393

实验名称：Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intr... 来源：ChEMBL 靶标：P2X purinoceptor 4 External Id：CHEMBL5126051

实验名称：Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intr... 来源：ChEMBL 靶标：P2X purinoceptor 7 External Id：CHEMBL5126052

实验名称：Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO... 来源：ChEMBL 靶标：P2X purinoceptor 7 External Id：CHEMBL5126053

实验名称：Agonist activity at human P2X1R expressing CHO cells assessed as reduction in intrace... 来源：ChEMBL 靶标：P2X purinoceptor 1 External Id：CHEMBL5126047

实验名称：Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intrace... 来源：ChEMBL 靶标：P2X purinoceptor 2 External Id：CHEMBL5126048

实验名称：Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intrace... 来源：ChEMBL 靶标：P2X purinoceptor 3 External Id：CHEMBL5126049

实验名称：Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in i... 来源：ChEMBL 靶标：P2X purinoceptor 3 External Id：CHEMBL5126050

实验名称：Substrate activity at recombinant full-length human CGAS expressed in Escherichia col... 来源：ChEMBL 靶标：Cyclic GMP-AMP synthase External Id：CHEMBL4338392

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