斑鸠菊内酯 B

• 常用名: 斑鸠菊内酯 B
• 英文名: Vernolide B
• CAS号: 618860-58-5
• 分子量: 434.48
• 密度: 1.2±0.1 g/cm3
• 沸点: 568.4±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₀O₈
• 熔点: N/A
• 闪点: 244.6±30.2 °C

斑鸠菊内酯 B用途

Vernolide-B具有细胞毒性(KB、NCI-661和HeLa细胞的ED50s:3.78、5.88、6.42μg/mL)。Vernolide B是一种倍半萜内酯,可从斑蝥中分离得到[1]。

斑鸠菊内酯 B名称

• 中文名: 斑鸠菊内酯 B
• 英文名: (1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate

斑鸠菊内酯 B生物活性

• 描述: Vernolide-B具有细胞毒性(KB、NCI-661和HeLa细胞的ED50s:3.78、5.88、6.42μg/mL)。Vernolide B是一种倍半萜内酯,可从斑蝥中分离得到[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Kuo YH, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2003 Apr;51(4):425-6.

斑鸠菊内酯 B物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 568.4±50.0 °C at 760 mmHg
• 分子式: C₂₃H₃₀O₈
• 分子量: 434.48
• 闪点: 244.6±30.2 °C
• 精确质量: 434.194061
• LogP: 3.47
• InChIKey: CIBBPLMBWXKCDP-UHFFFAOYSA-N
• SMILES: CC=C(C)C(=O)OC1CC(C)C2(OC)CCC(C)(C=C3OC(=O)C(COC(C)=O)=C31)O2
• 外观性状: 粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.539
• 储存条件: 2-8°C， 密封， 干燥， 避光

斑鸠菊内酯 B靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse NIH/3T3 cells at 5uM after 72 hrs by cyquant cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3630190

实验名称：Antiproliferative activity against human SF295 cells at 5 uM for 72 hrs by cyquant as... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3630189

实验名称：Antiproliferative activity against human MDA-MB-231 cells at 5 uM for 72 hrs by cyqua... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL3630188

实验名称：Anticlonogenic activity against human MCF7 cells for 72 hrs measured after 4 weeks by... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3630194

实验名称：Anticlonogenic activity against human MDA-MB-231 cells for 72 hrs measured after 2 we... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL3630193

实验名称：Anticlonogenic activity against human SF295 cells for 72 hrs by crystal-violet staini... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3630192

实验名称：Anticlonogenic activity against human U251MG cells for 72 hrs measured after 2 weeks ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3630191

实验名称：Cytotoxicity against human U251MG cells at 2.5 to 5 uM after 19 hrs 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3630198

实验名称：Inhibition of cell migration in human U251MG cells at 5 uM after 19 hrs by wound heal... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3630197

实验名称：Cytotoxicity against mouse NIH/3T3 cells assessed as colony survival at 1 to 5 uM for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3630195

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斑鸠菊内酯 B英文别名

• (1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate