Heliotrine N-oxide

• 常用名: Heliotrine N-oxide
• 英文名: Heliotrine N-oxide
• CAS号: 6209-65-0
• 分子量: 329.38900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₂₇NO₆
• 熔点: N/A
• 闪点: N/A

Heliotrine N-oxide用途

Heliotrine N-oxide 是 Heliotrine (HY-126128) 对应的吡咯利嗪生物碱类氮氧化物 (PA N-oxide)。Heliotrine N-oxide 可导致吡咯基 DNA 加合物 (DNA adduct) 的形成,并可能引发 PA 诱导的肝肿瘤的启动。

Heliotrine N-oxide名称

• 中文名: 天芥菜碱N-氧化物
• 英文名: heliotrine N-oxide

Heliotrine N-oxide生物活性

• 描述: Heliotrine N-oxide 是 Heliotrine (HY-126128) 对应的吡咯利嗪生物碱类氮氧化物 (PA N-oxide)。Heliotrine N-oxide 可导致吡咯基 DNA 加合物 (DNA adduct) 的形成,并可能引发 PA 诱导的肝肿瘤的启动。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: DNA加合物是与致癌化学物质结合的DNA片段。这个过程可能是癌细胞或癌变的开始。
• 参考文献:

  [1]. Xiaobo He, et al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.

Heliotrine N-oxide物理化学性质

• 分子式: C₁₆H₂₇NO₆
• 分子量: 329.38900
• 精确质量: 329.18400
• PSA: 105.42000
• LogP: 0.29820
• InChIKey: QSTHEUSPIBEICI-YGYDXHTPSA-N
• SMILES: COC(C)C(O)(C(=O)OCC1=CC[N+]2([O-])CCC(O)C12)C(C)C
• 外观性状: 粉末
• 储存条件: 2-8°C， 密封， 干燥， 避光

Heliotrine N-oxide靶点实验

查看更多实验

实验名称：Nematicidal activity against juvenile stage of Rhabditis sp. assessed as inhibition o... 来源：ChEMBL 靶标：Rhabditis sp. External Id：CHEMBL3080873

实验名称：Nematicidal activity against juvenile stage of Pratylenchus penetrans assessed as inh... 来源：ChEMBL 靶标：Pratylenchus penetrans External Id：CHEMBL3080875

实验名称：Nematicidal activity against juvenile stage of Meloidogyne incognita (root-knot nemat... 来源：ChEMBL 靶标：Meloidogyne incognita External Id：CHEMBL3080876

实验名称：Nematicidal activity against juvenile stage of Heterodera schachtii assessed as inhib... 来源：ChEMBL 靶标：Heterodera schachtii External Id：CHEMBL3080877

实验名称：Nematicidal activity against juvenile stage of Rhabditis sp. assessed as inhibition o... 来源：ChEMBL 靶标：Rhabditis sp. External Id：CHEMBL3080879

实验名称：Nematicidal activity against juvenile stage of Pratylenchus penetrans assessed as inh... 来源：ChEMBL 靶标：Pratylenchus penetrans External Id：CHEMBL3080880

实验名称：Nematicidal activity against juvenile stage of Meloidogyne incognita (root-knot nemat... 来源：ChEMBL 靶标：Meloidogyne incognita External Id：CHEMBL3080881

实验名称：Nematicidal activity against juvenile stage of Heterodera schachtii assessed as inhib... 来源：ChEMBL 靶标：Heterodera schachtii External Id：CHEMBL3080882

实验名称：Nematicidal activity against juvenile stage of Rhabditis sp. assessed as reduction of... 来源：ChEMBL 靶标：Rhabditis sp. External Id：CHEMBL3071262

实验名称：Nematicidal activity against juvenile stage of Rhabditis sp. assessed as reduction of... 来源：ChEMBL 靶标：Rhabditis sp. External Id：CHEMBL3071263

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Heliotrine N-oxide英文别名

• (2S,3R)-2-hydroxy-2-isopropyl-3-methoxy-butyric acid-((7aR)-7c-hydroxy-4-oxy-(4ξ,7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester)
• (2S,3R)-2-Hydroxy-2-isopropyl-3-methoxy-buttersaeure-((7aR)-7c-hydroxy-4-oxy-(4ξ,7ar)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethylester)
• [(7S,8S)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate