熊果酮酸

• 常用名: 熊果酮酸
• 英文名: Ursonic acid
• CAS号: 6246-46-4
• 分子量: 454.684
• 密度: 1.1±0.1 g/cm3
• 沸点: 555.1±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 熔点: 283 °C(dec.)
• 闪点: 303.6±26.6 °C

熊果酮酸用途

Ursonic acid是一种天然的三萜酸,可以通过多种信号通路诱发人类癌症细胞的细胞凋亡。

熊果酮酸名称

• 中文名: 3-氧代-12-烯-28-乌苏酸
• 英文名: 3-Oxours-12-en-28-oic acid
• 中文别名: 3-氧代乌索烷-12-烯-28-羧酸 | 熊果酮酸

熊果酮酸生物活性

• 描述: Ursonic acid是一种天然的三萜酸,可以通过多种信号通路诱发人类癌症细胞的细胞凋亡。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Gai, L., Cai, N., Wang, L., Xu, X. & Kong, X. Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells. Molecular medicine reports 7, 1673-1677, doi:10.3892/mmr.2013.1364 (2013).

  [2]. Manu, K. A. & Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. International immunopharmacology 8, 974-981, doi:10.1016/j.intimp.2008.02.013 (2008).

  [3]. Shanmugam, M. K. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. Journal of molecular medicine 89, 713-727, doi:10.1007/s00109-011-0746-2 (2011).

熊果酮酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 555.1±50.0 °C at 760 mmHg
• 熔点: 283 °C(dec.)
• 分子式: C₃₀H₄₆O₃
• 分子量: 454.684
• 闪点: 303.6±26.6 °C
• 精确质量: 454.344696
• PSA: 54.37000
• LogP: 8.43
• InChIKey: MUCRYNWJQNHDJH-OADIDDRXSA-N
• SMILES: CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C2C1C
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.550
• 储存条件: -20°C

熊果酮酸安全信息

• 海关编码: 2918300090

熊果酮酸海关

• 海关编码: 2918300090
• 中文概述: 2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

熊果酮酸靶点实验

查看更多实验

实验名称：Cytotoxicity against human THP1 cells at 50 uM after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3789085

实验名称：Cytotoxicity against human AsPC1 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：ASPC1 External Id：CHEMBL2148895

实验名称：Cytotoxicity against human A549 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL3789084

实验名称：Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3789083

实验名称：Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infect... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4185063

实验名称：Cytotoxicity against human MCF7 cells at 50 uM after 48 hrs by MTT assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3789089

实验名称：Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：Vero External Id：CHEMBL4185064

实验名称：Cytotoxicity against human A549 cells at 50 uM after 48 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL3789088

实验名称：Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4185065

实验名称：Cytotoxicity against human HCT116 cells at 50 uM after 48 hrs by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3789087

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熊果酮酸英文别名

• Ursonic acid
• Ursomic acid
• 3-Ketone
• 3-Oxours-12-en-28-oic acid
• ursonic acd
• 3-oxo-ursolic acid
• 3-oxo-12-ursen-28-oic acid