Ursonic acid
Modify Date: 2024-01-02 04:09:45
Ursonic acid structure
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Common Name | Ursonic acid | ||
|---|---|---|---|---|
| CAS Number | 6246-46-4 | Molecular Weight | 454.684 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 555.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C30H46O3 | Melting Point | 283 °C(dec.) | |
| MSDS | N/A | Flash Point | 303.6±26.6 °C | |
Use of Ursonic acidUrsolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways. In vitro: Ursolic acid is important in the induction of apoptosis via AKT/NF-κB signaling suppression in T24 human bladder cancer cells and this occurs in a dose-dependent manner. Thus, Akt and NF-κB are potential targets for bladder cancer therapy and ursolic acid may serve as a naturally-occurring candidate drug for the prevention and treatment of bladder cancer.[1]Ursolic acid induce apoptosis via inhibition of NF-κB induced BCl-2 mediated anti-apoptotic pathway leading to activation of p53 induced and caspase-3 mediated pro-apoptotic pathways.[2]In vivo: UA significantly suppressed prostate tumor growth in nude mice without any significant decrease in body weight. The systemic bioavailability of UA in serum samples obtained from nude mice. UA was detected in all serum samples 24 h after last injection. Systemic bioavailability of UA was in nanogram range and metabolites of UA were not detected in the samples. These results indicate that UA is well absorbed in the mouse peritoneum and supports the role of UA as a potent compound for chemoprevention and therapy of prostate cancer. [3] |
| Name | 3-Oxours-12-en-28-oic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Ursolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways. In vitro: Ursolic acid is important in the induction of apoptosis via AKT/NF-κB signaling suppression in T24 human bladder cancer cells and this occurs in a dose-dependent manner. Thus, Akt and NF-κB are potential targets for bladder cancer therapy and ursolic acid may serve as a naturally-occurring candidate drug for the prevention and treatment of bladder cancer.[1]Ursolic acid induce apoptosis via inhibition of NF-κB induced BCl-2 mediated anti-apoptotic pathway leading to activation of p53 induced and caspase-3 mediated pro-apoptotic pathways.[2]In vivo: UA significantly suppressed prostate tumor growth in nude mice without any significant decrease in body weight. The systemic bioavailability of UA in serum samples obtained from nude mice. UA was detected in all serum samples 24 h after last injection. Systemic bioavailability of UA was in nanogram range and metabolites of UA were not detected in the samples. These results indicate that UA is well absorbed in the mouse peritoneum and supports the role of UA as a potent compound for chemoprevention and therapy of prostate cancer. [3] |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 555.1±50.0 °C at 760 mmHg |
| Melting Point | 283 °C(dec.) |
| Molecular Formula | C30H46O3 |
| Molecular Weight | 454.684 |
| Flash Point | 303.6±26.6 °C |
| Exact Mass | 454.344696 |
| PSA | 54.37000 |
| LogP | 8.43 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.550 |
| Storage condition | -20°C |
| HS Code | 2918300090 |
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| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| Ursonic acid |
| Ursomic acid |
| 3-Ketone |
| 3-Oxours-12-en-28-oic acid |
| ursonic acd |
| 3-oxo-ursolic acid |
| Urs-12-en-28-oic acid, 3-oxo- |
| 3-oxo-12-ursen-28-oic acid |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Ursonic acid
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
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- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Ursonic acid
- Price: ￥Inquiry/5mg
- Purity: 97.0%
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ursonic acid
- Price: ￥3200.0/5mg
- Purity: 98.0%
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- DC Chemicals Limited
- China
- Product Name: Ursonic acid
- Price: $400.0/100mg $700.0/250mg $1350.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Ursonic acid
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-Oxours-12-en-28-oic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥918/100mg
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