OUL35

• 常用名: OUL35
• 英文名: OUL 35
• CAS号: 6336-34-1
• 分子量: 256.25700
• 密度: 1.298g/cm3
• 沸点: 488.8ºC at 760 mmHg
• 分子式: C₁₄H₁₂N₂O₃
• 熔点: N/A
• 闪点: 257.9ºC

OUL35用途

OUL35(NSC39047)是ARTD10(PARP-10)的有效和选择性抑制剂,IC50为329 nM[1]。

OUL35名称

• 英文名: 4-(4-carbamoylphenoxy)benzamide

OUL35生物活性

• 描述: OUL35(NSC39047)是ARTD10(PARP-10)的有效和选择性抑制剂,IC50为329 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> PARP
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 靶点实验:

  ARTD10/PARP10:329 nM (IC50)

• 体外研究: OUL35从ARTD10诱导的细胞死亡中拯救HeLa细胞,并使细胞对DNA损伤敏感。OUL35(3μM)与U2OS细胞中的内源性ARTD10结合[1]。OUL35还抑制ARTD8(23.4μM)、ARTD4(22.6μM)和ARTD15(4.17μM),但效力适中[1]。OUL35与Gly888的酰胺和羰基以及Ser927的侧链羟基形成氢键。OUL35堆叠在Tyr919和Tyr932之间,如晶体结构中的3AB[1]。
• 参考文献:

  [1]. Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260.

OUL35物理化学性质

• 密度: 1.298g/cm3
• 沸点: 488.8ºC at 760 mmHg
• 分子式: C₁₄H₁₂N₂O₃
• 分子量: 256.25700
• 闪点: 257.9ºC
• 精确质量: 256.08500
• PSA: 95.41000
• LogP: 3.07730
• InChIKey: XZRCQWLPMXFGHE-UHFFFAOYSA-N
• SMILES: NC(=O)c1ccc(Oc2ccc(C(N)=O)cc2)cc1
• 折射率: 1.633
• 储存条件: -20°C，密闭，干燥

OUL35靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Selectivity ratio of IC50 for full length human His-SUMO-tagged PARP11 expressed in E... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4311838

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

共158条，当前第1页，共16页

1

2

3

4

5

OUL35英文别名

• 4.4'-Oxy-bis-benzamid
• 4,4'-oxy-di-benzoic acid diamide
• 4,4'-oxydibenzamide
• 4,4'-Oxy-di-benzoesaeure-diamid