Ocrelizumab

• 常用名: Ocrelizumab
• 英文名: Ocrelizumab
• CAS号: 637334-45-3
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

Ocrelizumab用途

Ocrelizumab是一种抗CD20抗体,它耗尽循环中的未成熟和成熟B细胞,但保留CD20阴性浆细胞。Ocrelizumab的效应机制是补体依赖性细胞毒性和抗体依赖性细胞细胞毒性。Ocrelizumab是第一种治疗继发性原发性进行性多发性硬化症(PPMS)的单克隆抗体[1]。

Ocrelizumab名称

• 英文名: Ocrelizumab
• 中文别名: Ocrelizumab单抗

Ocrelizumab生物活性

• 描述: Ocrelizumab是一种抗CD20抗体,它耗尽循环中的未成熟和成熟B细胞,但保留CD20阴性浆细胞。Ocrelizumab的效应机制是补体依赖性细胞毒性和抗体依赖性细胞细胞毒性。Ocrelizumab是第一种治疗继发性原发性进行性多发性硬化症(PPMS)的单克隆抗体[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Mulero P, et al. Ocrelizumab: a new milestone in multiple sclerosis therapy. Ther Adv Neurol Disord. 2018 May 10;11:1756286418773025.

Ocrelizumab物理化学性质

暂时没有任何物化性质资料

Ocrelizumab靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytotoxicity against human Hep3B cells assessed as cell viability at 100 ug/ml measur... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL5216983

实验名称：Inhibition of PHD2 (unknown origin) at 66.7 uM relative to control 来源：ChEMBL 靶标：Egl nine homolog 1 External Id：CHEMBL5216982

实验名称：Cytotoxicity against human Hep3B cells assessed as cell viability at 12.5 ug/ml measu... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL5216984

实验名称：Antianemic activity in cisplatin-induced C57BL/6 mouse anemia model assessed as incre... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4669701

实验名称：Inhibition of PHD2 in human Hep3B cells assessed as stabilization of HIF-2alpha at 10... 来源：ChEMBL 靶标：Egl nine homolog 1 External Id：CHEMBL5216979

实验名称：In vivo inhibition of PHD2 in ICR mouse assessed as increase in serum EPO production ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5216978

实验名称：Inhibition of PHD2 in human Hep3B cells assessed as stabilization of HIF-1alpha at 10... 来源：ChEMBL 靶标：Egl nine homolog 1 External Id：CHEMBL5216980

实验名称：Nephroprotective activity against cisplatin-induced acute kidney injury in male C57BL... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5157645

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

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Ocrelizumab英文别名

• Monoclonal antibody Pro70769
• Pro-70769
• Pro70769
• Rhumab 2H7