尼莫唑

• 常用名: 尼莫唑
• 英文名: Nimorazole
• CAS号: 6506-37-2
• 分子量: 226.232
• 密度: 1.4±0.1 g/cm3
• 沸点: 443.0±35.0 °C at 760 mmHg
• 分子式: C₉H₁₄N₄O₃
• 熔点: N/A
• 闪点: 221.7±25.9 °C

尼莫唑用途

Nimorazole是抗感染类硝基咪唑。

尼莫唑名称

• 中文名: 尼莫拉唑
• 英文名: 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine
• 中文别名: 硝咪吗啉 | 硝咪乙吗 | 尼莫唑 | 4-[2-(5-硝基咪唑-1-基)乙基]吗啉

尼莫唑生物活性

• 描述: Nimorazole (K-1900) 是抗感染类硝基咪唑。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 靶点实验:

  Antiparasitic

• 体外研究: 尼莫拉唑显着改善了声门上咽和咽部肿瘤放射治疗的效果,并且可以给予没有重大副作用[1,2]。尼莫唑是唯一一种在头颈癌的随机对照试验中显示出显着效果的药物[3]。
• 参考文献:

  [1]. Overgaard, J., et al., A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol, 1998. 46(2): p. 135-46.

  [2]. Roy, R.B., S.M. Laird, and L. Heasman, Treatment of trichomoniasis in the female. A comparison of metronidazole and nimorazole. Br J Vener Dis, 1975. 51(4): p. 281-4.

  [3]. Henk, J.M., K. Bishop, and S.F. Shepherd, Treatment of head and neck cancer with CHART and nimorazole: phase II study. Radiother Oncol, 2003. 66(1): p. 65-70.

尼莫唑物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 443.0±35.0 °C at 760 mmHg
• 分子式: C₉H₁₄N₄O₃
• 分子量: 226.232
• 闪点: 221.7±25.9 °C
• 精确质量: 226.106583
• PSA: 76.11000
• LogP: -0.08
• InChIKey: MDJFHRLTPRPZLY-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])c1cncn1CCN1CCOCC1
• 外观性状: light yellow solid
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.637
• 储存条件: -20℃

尼莫唑毒性和生态

尼莫唑安全信息

• 海关编码: 2934999090

尼莫唑海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

尼莫唑靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

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尼莫唑英文别名

• Nulogyl
• 4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine
• 1-(β-Morpholinoethyl)-5-nitroimidazole
• Nimorazole
• Acterol
• Acterol forte
• Esclama
• Nimorazol
• 4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine
• Naxogin
• Nimorazolo
• UNII-469ULX0H4G
• Nitrimidazine
• Naxofem