RPR-260243

更新时间：2025-08-25 12:01:36

RPR-260243结构式	常用名	RPR-260243	英文名	RPR-260243
	CAS号	668463-35-2	分子量	510.50400
	密度	N/A	沸点	N/A
	分子式	C₂₈H₂₅F₃N₂O₄	熔点	N/A
	MSDS	N/A	闪点	N/A

RPR-260243用途

RPR-260243是HERG钾离子通道激活剂。

中文名	RPR-260243
英文名	(3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-3-carboxylic acid
英文别名	更多

描述	RPR-260243是HERG钾离子通道激活剂。
相关类别	信号通路 >> 跨膜转运 >> 钾通道研究领域 >> 心血管疾病
参考文献	[1]. Kang J, et al. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005 Mar;67(3):827-36.

分子式	C₂₈H₂₅F₃N₂O₄
分子量	510.50400
精确质量	510.17700
PSA	79.73000
LogP	4.63590
InChIKey	VWNMWKSURFWKAL-HXOBKFHXSA-N
SMILES	COc1ccc2nccc(C(=O)CCC3CCN(CC#Cc4cc(F)cc(F)c4F)CC3C(=O)O)c2c1
储存条件	2-8℃

实验名称：Activation of human ERG1 V549A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933614

实验名称：Activation of human ERG1 Y667A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933613

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Activation of human ERG1 F557L mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933617

实验名称：Activation of human ERG1 L550A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933615

实验名称：Activation of human ERG1 V659A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933610

实验名称：Activation of human ERG1 N658A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL925855

实验名称：Activation of human ERG1 L666A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933612

实验名称：Activation of human ERG1 I662A mutant expressed in Xenopus laevis oocytes assessed as...
来源：ChEMBL
靶标：Potassium voltage-gated channel subfamily H member 2
External Id：CHEMBL933611

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
来源：NCGC
External Id：CYP3A4437

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