JNK-IN-11

• 常用名: JNK-IN-11
• 英文名: JNK-IN-11
• CAS号: 676594-38-0
• 分子量: 281.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₁NO₃S₂
• 熔点: N/A
• 闪点: N/A

JNK-IN-11用途

JNK-IN-11(化合物1)是一种有效的JNK抑制剂,JNK1、JNK2和JNK3的IC50值分别为2.2、21.4和1.8µM。JNK-IN-11具有研究阿尔茨海默病和帕金森病的潜力[1]。

JNK-IN-11名称

• 英文名: JNK-IN-11

JNK-IN-11生物活性

• 描述: JNK-IN-11(化合物1)是一种有效的JNK抑制剂,JNK1、JNK2和JNK3的IC50值分别为2.2、21.4和1.8µM。JNK-IN-11具有研究阿尔茨海默病和帕金森病的潜力[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> MAPK/ERK信号通路 >> JNK
• 靶点实验:

  JNK1:1.8 μM (IC50)

  JNK3:2.2 μM (IC50)

  JNK2:21.4 μM (IC50)

• 参考文献:

  [1]. Hom RK, et al. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7.

JNK-IN-11物理化学性质

• 分子式: C₁₂H₁₁NO₃S₂
• 分子量: 281.35
• InChIKey: CXOCENPNQSXLGZ-UHFFFAOYSA-N
• SMILES: COC(=O)c1sccc1NC(=O)Cc1cccs1

JNK-IN-11靶点实验

查看更多实验

实验名称：Selectivity ratio of IC50 for recombinant JNK2 to IC50 for recombinant JNK3 来源：ChEMBL 靶标：N/A External Id：CHEMBL1291183

实验名称：Selectivity ratio of IC50 for recombinant JNK2 to IC50 for recombinant JNK1 来源：ChEMBL 靶标：N/A External Id：CHEMBL1291184

实验名称：Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 8 External Id：CHEMBL1291185

实验名称：Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 9 External Id：CHEMBL1291186

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 10 External Id：CHEMBL1291187

实验名称：Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL1686762

实验名称：Apparent permeability of the compound from apical to basolateral direction in MDCK2 c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1686764

实验名称：Efflux ratio of permeability from basolateral to apical side over apical to basolater... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1686765

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

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