地黄苷

• 常用名: 地黄苷
• 英文名: Martynoside
• CAS号: 67884-12-2
• 分子量: 652.64
• 密度: 1.5±0.1 g/cm3
• 沸点: 865.1±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₀O₁₅
• 熔点: N/A
• 闪点: 274.9±27.8 °C

地黄苷用途

Martynoside通过下调TNF信号通路保护离体骨髓细胞免受5-氟尿嘧啶(5-FU)诱导的细胞死亡和炎症反应[1]。Martynoside是MCF-7细胞中一种有效的抗雌激素药物,可提高IGFBP3水平

地黄苷名称

• 中文名: 地黄苷
• 英文名: [(2R,3R,4R,5R,6R)-5-hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

地黄苷生物活性

• 描述: Martynoside通过下调TNF信号通路保护离体骨髓细胞免受5-氟尿嘧啶(5-FU)诱导的细胞死亡和炎症反应[1]。Martynoside是MCF-7细胞中一种有效的抗雌激素药物,可提高IGFBP3水平
• 相关类别:
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Hong M, et al. Ex vivo and in vivo chemoprotective activity and potential mechanism of Martynoside against 5-fluorouracil-induced bone marrow cytotoxicity. Biomed Pharmacother. 2021;138:111501.

  [2]. Papoutsi Z,et al. Acteoside and martynoside exhibit estrogenic/antiestrogenic properties. J Steroid Biochem Mol Biol. 2006;98(1):63-71.

地黄苷物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 865.1±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₀O₁₅
• 分子量: 652.64
• 闪点: 274.9±27.8 °C
• 精确质量: 652.236694
• PSA: 223.29000
• LogP: 2.96
• InChIKey: WLWAYPFRKDSFCL-CNMJWYMJSA-N
• SMILES: COc1ccc(CCOC2OC(CO)C(OC(=O)C=Cc3ccc(O)c(OC)c3)C(OC3OC(C)C(O)C(O)C3O)C2O)cc1O
• 外观性状: 粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.641
• 储存条件: 2-8℃，干燥，密闭

地黄苷安全信息

• 危害码 (欧洲): Xi

地黄苷靶点实验

查看更多实验

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio a... 来源：ChEMBL 靶标：Raji External Id：CHEMBL1004259

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio af... 来源：ChEMBL 靶标：Raji External Id：CHEMBL1004260

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 mo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1004257

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio a... 来源：ChEMBL 靶标：Raji External Id：CHEMBL1004258

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 mol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1004255

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 mol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1004256

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio ... 来源：ChEMBL 靶标：Raji External Id：CHEMBL1004253

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 mola... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1004254

实验名称：Antioxidant activity assessed as protection against peroxyl radical-induced alkaline ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1033660

实验名称：Antibacterial activity against Staphylococcus aureus assessed as growth inhibition af... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3390351

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地黄苷英文别名

• 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-4-O-[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]-β-D-glucopyranoside
• Martynoside
• 2-(3-Hydroxy-4-methoxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-4-O-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoyl]-β-D-glucopyranoside
• martynoside A