乌心石内酯

• 常用名: 乌心石内酯
• 英文名: Micheliolide
• CAS号: 68370-47-8
• 分子量: 248.318
• 密度: 1.2±0.1 g/cm3
• 沸点: 426.1±45.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 熔点: N/A
• 闪点: 181.8±21.5 °C

乌心石内酯用途

Micheliolide能减弱高糖刺激的NF-κB活化,IκBα的降解,和MCP-1,TGF-β1,FN在鼠系膜细胞的表达。

乌心石内酯名称

• 中文名: 乌心石内酯(木香内酯)
• 英文名: (3aS,9R,9aS,9bS)-9-hydroxy-6,9-dimethyl-3-methylidene-4,5,7,8,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2-one
• 中文别名: 木香内酯

乌心石内酯生物活性

• 描述: Micheliolide能减弱高糖刺激的NF-κB活化,IκBα的降解,和MCP-1,TGF-β1,FN在鼠系膜细胞的表达。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18(10):13061-77.

乌心石内酯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 426.1±45.0 °C at 760 mmHg
• 分子式: C₁₅H₂₀O₃
• 分子量: 248.318
• 闪点: 181.8±21.5 °C
• 精确质量: 248.141251
• PSA: 46.53000
• LogP: 2.14
• InChIKey: RDJAFOWISVMOJY-PWNZVWSESA-N
• SMILES: C=C1C(=O)OC2C1CCC(C)=C1CCC(C)(O)C12
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.555
• 储存条件: -20°C

乌心石内酯靶点实验

查看更多实验

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+CD3... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210164

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+ ce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210165

实验名称：Induction of apoptosis in CD34+ leukemia stem/progenitor cells assessed as necrotic c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2210162

实验名称：Activation of PKM2 (unknown origin) Leu353, Ala388, Tyr390, Lys311, Asn350 residues 来源：ChEMBL 靶标：Pyruvate kinase PKM External Id：CHEMBL5137761

实验名称：Cytotoxicity against human leukemia stem/progenitor cells assessed as viable CD34+ ce... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210580

实验名称：Reduction in colony forming units of leukemia stem/progenitor cells at 10 uM after 15... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210157

实验名称：Cytotoxicity against human CD34+ hematopioetic stem cells at 5 uM by immunostaining m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2210154

实验名称：Induction of apoptosis in CD34+ leukemia stem/progenitor cells assessed as early apop... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2210160

实验名称：Induction of apoptosis in CD34+ leukemia stem/progenitor cells assessed as late apopt... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2210161

实验名称：Reduction in colony forming units of leukemia stem/progenitor cells at 5 uM after 15 ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2210158

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乌心石内酯英文别名

• (3aS,9R,9aS,9bS)-9-Hydroxy-6,9-dimethyl-3-methylene-3a,4,5,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-2(3H)-one
• Mecheliolide
• MICHELIOLIDE