Micheliolide

Modify Date: 2025-08-25 11:53:43

Micheliolide Structure
Micheliolide structure
Common Name Micheliolide
CAS Number 68370-47-8 Molecular Weight 248.318
Density 1.2±0.1 g/cm3 Boiling Point 426.1±45.0 °C at 760 mmHg
Molecular Formula C15H20O3 Melting Point N/A
MSDS N/A Flash Point 181.8±21.5 °C

 Use of Micheliolide


Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

 Names

Name (3aS,9R,9aS,9bS)-9-hydroxy-6,9-dimethyl-3-methylidene-4,5,7,8,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2-one
Synonym More Synonyms

 Micheliolide Biological Activity

Description Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).
Related Catalog
References

[1]. Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18(10):13061-77.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 426.1±45.0 °C at 760 mmHg
Molecular Formula C15H20O3
Molecular Weight 248.318
Flash Point 181.8±21.5 °C
Exact Mass 248.141251
PSA 46.53000
LogP 2.14
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.555
Storage condition -20°C

 Synonyms

Azuleno[4,5-b]furan-2(3H)-one, 3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-, (3aS,9R,9aS,9bS)-
(3aS,9R,9aS,9bS)-9-Hydroxy-6,9-dimethyl-3-methylene-3a,4,5,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-2(3H)-one
Mecheliolide
MICHELIOLIDE
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