GSK 264220A

• 常用名: GSK 264220A
• 英文名: GSK 264220A
• CAS号: 685506-42-7
• 分子量: 363.431
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₇H₂₁N₃O₄S
• 熔点: N/A
• 闪点: N/A

GSK 264220A用途

GSK264220A是一种有效的内皮脂肪酶抑制剂,IC50为16 nM。GSK264220A具有降低心血管疾病风险的潜力[1]。

GSK 264220A名称

• 英文名: 1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea

GSK 264220A生物活性

• 描述: GSK264220A是一种有效的内皮脂肪酶抑制剂,IC50为16 nM。GSK264220A具有降低心血管疾病风险的潜力[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Keller PM, et al. A high-throughput screen for endothelial lipase using HDL as substrate. J Biomol Screen. 2008 Jul;13(6):468-75.

GSK 264220A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₇H₂₁N₃O₄S
• 分子量: 363.431
• 精确质量: 363.125275
• PSA: 100.03000
• LogP: 2.01
• InChIKey: LVOVQRPAMXCXTM-UHFFFAOYSA-N
• SMILES: Cc1oc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Nc1ccccc1
• 折射率: 1.633

GSK 264220A靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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GSK 264220A英文别名

• 1-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furyl]-3-phenylurea
• 1-[2-Methyl-5-(piperidin-1-ylsulfonyl)-3-furyl]-3-phenylurea
• N-[2-methyl-5-(piperidinosulfonyl)-3-furyl]-N'-phenylurea