泽兰苦素

• 常用名: 泽兰苦素
• 英文名: eupatoriopicrine
• CAS号: 6856-01-5
• 分子量: 362.42
• 密度: 1.1481 (rough estimate)
• 沸点: 414.03°C (rough estimate)
• 分子式: C₂₀H₂₆O₆
• 熔点: N/A
• 闪点: N/A

泽兰苦素用途

Eupatoriocrin是一种抗锥虫病药物,IC50值为1.2μM(T.b.Rhodesense)。Eupatoriocrin对L6细胞具有细胞毒性,IC50值为1.6μM[1]。

泽兰苦素名称

• 中文名: 泽兰苦素
• 英文名: Eupatoriopicrin

泽兰苦素生物活性

• 描述: Eupatoriocrin是一种抗锥虫病药物,IC50值为1.2μM(T.b.Rhodesense)。Eupatoriocrin对L6细胞具有细胞毒性,IC50值为1.6μM[1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Julianti T, et a. Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia. 2011 Oct;82(7):955-9.

泽兰苦素物理化学性质

• 密度: 1.1481 (rough estimate)
• 沸点: 414.03°C (rough estimate)
• 分子式: C₂₀H₂₆O₆
• 分子量: 362.42
• 精确质量: 362.17300
• PSA: 93.06000
• LogP: 1.98350
• InChIKey: VWJYWGYJIDQUEG-DKDOXNMLSA-N
• SMILES: C=C1C(=O)OC2C=C(C)CCC=C(C)CC(OC(=O)C(=CCO)CO)C12
• 折射率: 1.4450 (estimate)

泽兰苦素靶点实验

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实验名称：Inhibition of Pseudomonas aeruginosa PAO1293 MurA in presence of UNAG 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL911297

实验名称：Inhibition of Escherichia coli K12 Mur A C115D at 50 uM in presence of UNAG 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL911298

实验名称：Inhibition of MurA at 10 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL911300

实验名称：Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D-glucopyr... 来源：ChEMBL 靶标：Maltase-glucoamylase External Id：CHEMBL5054848

实验名称：Cytotoxicity against human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL994932

实验名称：Cytotoxicity against mouse EAC after 3 days by MTT assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1021027

实验名称：Inhibition of Escherichia coli K12 Mur A in presence of UNAG 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL911296

实验名称：Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluoresc... 来源：ChEMBL 靶标：L6 External Id：CHEMBL4136590

实验名称：Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhod... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4136591

实验名称：Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction i... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 2 External Id：CHEMBL5054847

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泽兰苦素英文别名

• 6α-[Hydroxy-8β-(4-Hydroxy-2-hydroxymethyl-trans-crotonoyloxy)-germacra-1(10)t,4t,11(13)-trien-12-saeure-6-lacton
• (E)-4-Hydroxy-2-hydroxymethyl-but-2-enoic acid (6E,10E)-(3aR,4R,11aR)-6,10-dimethyl-3-methylene-2-oxo-2,3,3a,4,5,8,9,11a-octahydro-cyclodeca[b]furan-4-yl ester
• 6α-[hydroxy-8β-(4-hydroxy-2-hydroxymethyl-trans-crotonoyloxy)-germacra-1(10)t,4t,11(13)-trien-12-oic acid-6-lactone