D-I03

• 常用名: D-I03
• 英文名: D-I03
• CAS号: 688342-78-1
• 分子量: 428.643
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₆N₆S
• 熔点: N/A
• 闪点: N/A

D-I03用途

D-I03(D-103)是一种小分子,抑制RAD52介导的ssDNA退火,IC50为5 uM,与RAD52结合,Kd为25.8 uM,抑制D环形成,体外IC50为8 uM；抑制BRCA1的生长-和BRCA2缺陷细胞(浓度为2.5 uM)并抑制人U2OS细胞中RAD52介导的SSA；对SSA选择性同源重组(HR)。

D-I03名称

• 英文名: D-I03

D-I03生物活性

• 描述: D-I03(D-103)是一种小分子,抑制RAD52介导的ssDNA退火,IC50为5 uM,与RAD52结合,Kd为25.8 uM,抑制D环形成,体外IC50为8 uM；抑制BRCA1的生长-和BRCA2缺陷细胞(浓度为2.5 uM)并抑制人U2OS细胞中RAD52介导的SSA；对SSA选择性同源重组(HR)。
• 参考文献: References 1. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. View Related Products by Target DNA Repair Protein

D-I03物理化学性质

• 分子式: C₂₃H₃₆N₆S
• 分子量: 428.643
• InChIKey: UXDGHRWOHOPKIL-UHFFFAOYSA-N
• SMILES: CCN(CC)CCNC(=S)Nc1ccc2nc(N3CCN(CC)CC3)cc(C)c2c1
• 储存条件: 2-8°C，干燥，密封

D-I03安全信息

• 危害码 (欧洲): Xi

D-I03靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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