4'-C-迭氮基胞嘧啶核苷 2',3',5'-三异丁酸酯

• 常用名: 4'-C-迭氮基胞嘧啶核苷 2',3',5'-三异丁酸酯
• 英文名: Balapiravir
• CAS号: 690270-29-2
• 分子量: 494.49800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₃₀N₆O₈
• 熔点: N/A
• 闪点: N/A

用途

Balapiravir (R1626, Ro 4588161)是R1479(RG1479)的原药,是HCV的RNA聚合酶核苷类似物抑制剂。

名称

• 中文名: 4'-C-迭氮基胞嘧啶核苷 2',3',5'-三异丁酸酯
• 英文名: isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-4-isobutyryloxy-2-isobutyryloxymethyltetrahydrofuran-3-yl ester

生物活性

• 描述: Balapiravir (R1626, Ro 4588161)是R1479(RG1479)的原药,是HCV的RNA聚合酶核苷类似物抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> HCV
  研究领域 >> 感染
• 参考文献:

  [1]. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450.

  [2]. Nelson DR, et al. Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.Ann Hepatol. 2012 Jan-Feb;11(1):15-31.

  [3]. Li F, et al. Chemical stability of 4'-azidocytidine and its prodrug balapiravir.Drug Dev Ind Pharm. 2010 Apr;36(4):413-20.

  [4]. kros PJ, et al. R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin.Hepatology. 2008 Aug;48(2):385-97.

  [5]. Roberts SK, et al. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C.Hepatology. 2008 Aug;48(2):398-406.

  [6]. Chen YL, et al. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol. 2014 Feb;88(3):1740-1747.

物理化学性质

• 分子式: C₂₁H₃₀N₆O₈
• 分子量: 494.49800
• 精确质量: 494.21300
• PSA: 198.79000
• LogP: 1.72966
• 储存条件: 2-8℃

英文别名

• Balapiravir