5-乙炔啶(5-EU)

• 常用名: 5-乙炔啶(5-EU)
• 英文名: 5-Ethynyl uridine
• CAS号: 69075-42-9
• 分子量: 268.22300
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₂N₂O₆
• 熔点: N/A
• 闪点: N/A

5-乙炔啶(5-EU)用途

5-乙基尿苷(5-EU)是一种有效的细胞可渗透核苷,可用于标记新合成的RNA。5-乙炔尿苷可用于从体内神经元群体中分离和测序新生RNA。5-乙炔尿苷可用于识别神经系统疾病模型体内转录的变化[1][2]。

5-乙炔啶(5-EU)名称

• 中文名: 5-乙炔基尿苷
• 英文名: 5-ethynyluridine
• 中文别名: 5-乙炔基尿嘧啶核苷 | 5-乙炔基尿甙

5-乙炔啶(5-EU)生物活性

• 描述: 5-乙基尿苷(5-EU)是一种有效的细胞可渗透核苷,可用于标记新合成的RNA。5-乙炔尿苷可用于从体内神经元群体中分离和测序新生RNA。5-乙炔尿苷可用于识别神经系统疾病模型体内转录的变化[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体内研究: 5-乙炔尿苷(PBS中75 mM,1µl；小脑内注射)显示小鼠中枢神经系统细胞的标记[1]。5-乙炔尿苷(330-750µMol/g；i.p.)导致标记多器官和组织细胞中的新生RNA,但不标记小鼠的中枢神经系统[1]。
• 参考文献:

  [1]. Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94.

  [2]. Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84.

5-乙炔啶(5-EU)物理化学性质

• 分子式: C₁₁H₁₂N₂O₆
• 分子量: 268.22300
• 精确质量: 268.07000
• PSA: 124.78000
• InChIKey: QCWBIPKYTBFWHH-FDDDBJFASA-N
• SMILES: C#Cc1cn(C2OC(CO)C(O)C2O)c(=O)[nH]c1=O
• 储存条件: 2-8°C，干燥密封

5-乙炔啶(5-EU)靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as 100% redu... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3863160

实验名称：Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as 100% redu... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL3863161

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 assessed as 100% reduction... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL3863162

实验名称：Antibacterial activity against clinical isolates of Salmonella typhimurium assessed a... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL3863163

实验名称：Growth inhibition of Staphylococcus aureus ATCC 25923 at 100 ug/ml after 6 days in pr... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3863156

实验名称：Growth inhibition of Staphylococcus aureus ATCC 25923 assessed as fractional inhibito... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3863157

实验名称：Growth inhibition of Enterococcus faecalis ATCC 29212 at 100 ug/ml after 6 days in pr... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL3863158

实验名称：Growth inhibition of Enterococcus faecalis ATCC 29212 assessed as fractional inhibito... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL3863159

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 13048 assessed as 100% red... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL3863164

实验名称：Cytotoxicity against African green monkey Vero cells assessed as decrease in cell via... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3863135

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5-乙炔啶(5-EU)英文别名

• 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione
• 5-ETHYNYL URIDINE