2'-fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine

• 常用名: 2'-fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine
• 英文名: 2'-fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine
• CAS号: 69123-93-9
• 分子量: 324.10
• 密度: 2.21 g/cm3
• 沸点: 513.3ºC at 760 mmHg
• 分子式: C₉H₁₁BrFN₃O₄
• 熔点: N/A
• 闪点: 264.3ºC

用途

5-溴-2'-脱氧-2'-氟-β-D-阿拉伯胞苷是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。

名称

• 英文名: 4-amino-5-bromo-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

生物活性

• 描述: 5-溴-2'-脱氧-2'-氟-β-D-阿拉伯胞苷是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

物理化学性质

• 密度: 2.21 g/cm3
• 沸点: 513.3ºC at 760 mmHg
• 分子式: C₉H₁₁BrFN₃O₄
• 分子量: 324.10
• 闪点: 264.3ºC
• 精确质量: 338.98700
• PSA: 130.83000
• InChIKey: DPTQLSGNVUCAMZ-BYPJNBLXSA-N
• SMILES: Nc1nc(=O)n(C2OC(CO)C(O)C2F)cc1Br
• 折射率: 1.741

靶点实验

查看更多实验

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英文别名

• 2'-Fluoro-5-bromo-aracytosine