GO289

• 常用名: GO289
• 英文名: GO289
• CAS号: 694522-87-7
• 分子量: 419.297
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅BrN₄O₂S
• 熔点: N/A
• 闪点: N/A

GO289用途

GO289(GO-289,GO 289)是酪蛋白激酶2(CK2)的有效选择性抑制剂,在体外激酶测定中IC50为7 nM,对体外CKIδ和CKIα活性影响较小；GO289仅显示中度或对来自各种类别的59种激酶的活性的轻微影响,第二受影响最大的激酶是PIM2,IC50为13nM；不仅在Bmal1-dLuc报告细胞中而且在具有与Bmal1-dLuc相反的相的Per2-dLuc报告细胞中引起昼夜节律的剂量依赖性延长,抑制细胞中时钟蛋白Per2 S693的磷酸化；强烈抑制Caki-2,A498和769-P癌细胞,显着降低小鼠MLL-AF9白血病细胞的生长而不影响造血祖细胞；显示对MLL-AF9小鼠的脾外植体中的昼夜节律和报告信号强度的有效性。

GO289名称

• 英文名: GO289

GO289生物活性

• 描述: GO289(GO-289,GO 289)是酪蛋白激酶2(CK2)的有效选择性抑制剂,在体外激酶测定中IC50为7 nM,对体外CKIδ和CKIα活性影响较小；GO289仅显示中度或对来自各种类别的59种激酶的活性的轻微影响,第二受影响最大的激酶是PIM2,IC50为13nM；不仅在Bmal1-dLuc报告细胞中而且在具有与Bmal1-dLuc相反的相的Per2-dLuc报告细胞中引起昼夜节律的剂量依赖性延长,抑制细胞中时钟蛋白Per2 S693的磷酸化；强烈抑制Caki-2,A498和769-P癌细胞,显着降低小鼠MLL-AF9白血病细胞的生长而不影响造血祖细胞；显示对MLL-AF9小鼠的脾外植体中的昼夜节律和报告信号强度的有效性。
• 参考文献: References 1. Tsuyoshi Oshima, et al. Science Advances 23 Jan 2019: Vol. 5, no. 1, eaau9060. DOI: 10.1126/sciadv.aau9060. View Related Products by Target Casein Kinase

GO289物理化学性质

• 分子式: C₁₇H₁₅BrN₄O₂S
• 分子量: 419.297
• InChIKey: DARDDBZKGVEVKB-VXLYETTFSA-N
• SMILES: COc1cc(C=Nn2c(SC)nnc2-c2ccccc2)c(Br)cc1O
• 储存条件: 2-8°C，干燥，密封

GO289安全信息

• 危害码 (欧洲): Xi

GO289靶点实验

查看更多实验

实验名称：Inhibition of Nop56 in mouse C2C12 cells assessed as reduction in phospho-sites occup... 来源：ChEMBL 靶标：Nucleolar protein 56 External Id：CHEMBL4815398

实验名称：Inhibition of Stria-tin in mouse C2C12 cells assessed as reduction in phospho-sites o... 来源：ChEMBL 靶标：Striatin External Id：CHEMBL4815425

实验名称：Inhibition of Sequestosome-1 in mouse C2C12 cells assessed as reduction in phospho-si... 来源：ChEMBL 靶标：Sequestosome-1 External Id：CHEMBL4815426

实验名称：Inhibition of Edc4 in mouse C2C12 cells assessed as reduction in phospho-sites occupa... 来源：ChEMBL 靶标：Enhancer of mRNA-decapping protein 4 External Id：CHEMBL4815423

实验名称：Inhibition of Ehd2 in mouse C2C12 cells assessed as reduction in phospho-sites occupa... 来源：ChEMBL 靶标：EH domain-containing protein 2 External Id：CHEMBL4815424

实验名称：Inhibition of Pja1 in mouse C2C12 cells assessed as reduction in phospho-sites occupa... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Praja-1 External Id：CHEMBL4815429

实验名称：Inhibition of Gbf1 in mouse C2C12 cells assessed as reduction in phospho-sites occupa... 来源：ChEMBL 靶标：Prostaglandin E synthase 2 External Id：CHEMBL4815430

实验名称：Inhibition of Srrm1 in mouse C2C12 cells assessed as reduction in phospho-sites occup... 来源：ChEMBL 靶标：Serine/arginine repetitive matrix protein 1 External Id：CHEMBL4815427

实验名称：Inhibition of Lima1 in mouse C2C12 cells assessed as reduction in phospho-sites occup... 来源：ChEMBL 靶标：LIM domain and actin-binding protein 1 External Id：CHEMBL4815428

实验名称：Inhibition of Cep170 in mouse C2C12 cells assessed as reduction in phospho-sites occu... 来源：ChEMBL 靶标：Centrosomal protein of 170 kDa External Id：CHEMBL4815417

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