6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

• 常用名: 6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
• 英文名: 6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
• CAS号: 697299-82-4
• 分子量: 474.91400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₀ClFN₄O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

物理化学性质

• 分子式: C₂₆H₂₀ClFN₄O₂
• 分子量: 474.91400
• 精确质量: 474.12600
• PSA: 86.20000
• LogP: 7.23690
• InChIKey: NQHFMDSFFGTFSK-UHFFFAOYSA-N
• SMILES: NCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1

靶点实验

查看更多实验

实验名称：Activity of recombinant CYP3A5 (unknown origin) assessed as compound formation treate... 来源：ChEMBL 靶标：Cytochrome P450 3A5 External Id：CHEMBL3531377

实验名称：Drug level in human liver microsomes treated with lapatinib at 50 uM by LC/MS/MS anal... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3527791

实验名称：Activity of recombinant CYP3A4 (unknown origin) assessed as compound formation treate... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL3527792

实验名称：Activity of recombinant CYP3A5 (unknown origin) assessed as compound formation treate... 来源：ChEMBL 靶标：Cytochrome P450 3A5 External Id：CHEMBL3531386

实验名称：Drug level in human liver microsomes treated with lapatinib at 50 uM for 30 mins afte... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3531384

实验名称：Activity of recombinant CYP3A4 (unknown origin) assessed as compound formation treate... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL3531385

实验名称：Drug level in healthy human feces treated with [14C]lapatinib at 250 mg, po administe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3536947

实验名称：Retention time of the compound by LC/MS/MS analysis relative to lapatinib 来源：ChEMBL 靶标：N/A External Id：CHEMBL3529323

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英文别名

• N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-(aminomethyl)-2-furyl]-4-quinazolinamine
• [6-(5-Aminomethylfuran-2-yl)quinazolin-4-yl][3-chloro-4-(3-fluorobenzyloxy)phenyl]amine
• 6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine
• N-De[2-(methylsulfonyl)ethyl] Lapatinib