6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

Modify Date: 2026-08-16 12:27:26

6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine structure	Common Name	6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
	CAS Number	697299-82-4	Molecular Weight	474.91400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₀ClFN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Name	6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
Synonym	More Synonyms

Molecular Formula	C₂₆H₂₀ClFN₄O₂
Molecular Weight	474.91400
Exact Mass	474.12600
PSA	86.20000
LogP	7.23690
InChIKey	NQHFMDSFFGTFSK-UHFFFAOYSA-N
SMILES	NCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1

(5-{4-[3-Chloro...

CAS#:697299-81-3

~10%

6-[5-(aminometh...

CAS#:697299-82-4

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Literature: Wallace, Eli; Topolov, George; Zhao, Qian; Lyssikatos, Joseph P. Patent: US2005/101617 A1, 2005 ; Location in patent: Page/Page column 9 ;

Precursor 1
CAS#:697299-81-3 (5-{4-[3-Chloro...
DownStream 0

Name: Activity of recombinant CYP3A5 (unknown origin) assessed as compound formation treate...
Source: ChEMBL
Target: Cytochrome P450 3A5
External Id: CHEMBL3531377

Name: Drug level in human liver microsomes treated with lapatinib at 50 uM by LC/MS/MS anal...
Source: ChEMBL
Target: Liver microsome
External Id: CHEMBL3527791

Name: Activity of recombinant CYP3A4 (unknown origin) assessed as compound formation treate...
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL3527792

Name: Activity of recombinant CYP3A5 (unknown origin) assessed as compound formation treate...
Source: ChEMBL
Target: Cytochrome P450 3A5
External Id: CHEMBL3531386

Name: Drug level in human liver microsomes treated with lapatinib at 50 uM for 30 mins afte...
Source: ChEMBL
Target: Liver microsome
External Id: CHEMBL3531384

Name: Activity of recombinant CYP3A4 (unknown origin) assessed as compound formation treate...
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL3531385

Name: Drug level in healthy human feces treated with [14C]lapatinib at 250 mg, po administe...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3536947

Name: Retention time of the compound by LC/MS/MS analysis relative to lapatinib
Source: ChEMBL
Target: N/A
External Id: CHEMBL3529323

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N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-(aminomethyl)-2-furyl]-4-quinazolinamine

[6-(5-Aminomethylfuran-2-yl)quinazolin-4-yl][3-chloro-4-(3-fluorobenzyloxy)phenyl]amine

6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine

N-De[2-(methylsulfonyl)ethyl] Lapatinib

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

6-[5-(aminomethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine

Names

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.