GLX481304

• 常用名: GLX481304
• 英文名: GLX481304
• CAS号: 701224-63-7
• 分子量: 419.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₉N₇O
• 熔点: N/A
• 闪点: N/A

GLX481304用途

GLX481304是Nox-2和-4的特异性抑制剂,IC50为1.25μM。GLX481304抑制分离的小鼠心肌细胞中ROS的产生并改善心肌细胞的收缩性。GLX481304可用于心脏缺血性损伤的研究[1]。

GLX481304名称

• 英文名: GLX481304

GLX481304生物活性

• 描述: GLX481304是Nox-2和-4的特异性抑制剂,IC50为1.25μM。GLX481304抑制分离的小鼠心肌细胞中ROS的产生并改善心肌细胞的收缩性。GLX481304可用于心脏缺血性损伤的研究[1]。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点实验:

  Nox-2/4[1]

• 参考文献:

  [1]. Szekeres FLM, et al. A small molecule inhibitor of Nox2 and Nox4 improves contractile function after ischemia-reperfusion in the mouse heart. Sci Rep. 2021 Jun 7;11(1):11970.

GLX481304物理化学性质

• 分子式: C₂₃H₂₉N₇O
• 分子量: 419.52
• InChIKey: STKSULQULJWEMU-UHFFFAOYSA-N
• SMILES: COc1cccc(N2CCN(Cc3nc(N)nc(Nc4ccc(C)c(C)c4)n3)CC2)c1

GLX481304靶点实验

查看更多实验

实验名称：Nox4 Assay from US Patent US10173988: "N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperaz... 来源：BindingDB 靶标：N/A External Id：BindingDB_1374_3

实验名称：Nox2 Assay from US Patent US10173988: "N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperaz... 来源：BindingDB 靶标：N/A External Id：BindingDB_1374_2

实验名称：Nox1 Assay from US Patent US10173988: "N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperaz... 来源：BindingDB 靶标：N/A External Id：BindingDB_1374_1

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

共6条，当前第1页，共1页

1