GLX481304

Modify Date: 2024-01-12 14:08:02

GLX481304 Structure
GLX481304 structure
Common Name GLX481304
CAS Number 701224-63-7 Molecular Weight 419.52
Density N/A Boiling Point N/A
Molecular Formula C23H29N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GLX481304


GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart[1].

 Names

Name GLX481304

 GLX481304 Biological Activity

Description GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart[1].
Related Catalog
Target

Nox-2/4[1]

References

[1]. Szekeres FLM, et al. A small molecule inhibitor of Nox2 and Nox4 improves contractile function after ischemia-reperfusion in the mouse heart. Sci Rep. 2021 Jun 7;11(1):11970.  

 Chemical & Physical Properties

Molecular Formula C23H29N7O
Molecular Weight 419.52
InChIKey STKSULQULJWEMU-UHFFFAOYSA-N
SMILES COc1cccc(N2CCN(Cc3nc(N)nc(Nc4ccc(C)c(C)c4)n3)CC2)c1
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