N,N-dimethyldoxorubicin

• 常用名: N,N-dimethyldoxorubicin
• 英文名: N,N-dimethyldoxorubicin
• CAS号: 70222-95-6
• 分子量: 571.57200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₃NO₁₁
• 熔点: N/A
• 闪点: N/A

N,N-dimethyldoxorubicin用途

N,N-Dimethyldoxorubicin 是一种阿霉素 (Doxorubicin (HY-15142A)) 类似物。N,N-Dimethyldoxorubicin 对一一系列肿瘤细胞系具有细胞毒性 (IC50s < 0.3 μM)。

N,N-dimethyldoxorubicin名称

• 英文名: nsc 261045

N,N-dimethyldoxorubicin生物活性

• 描述: N,N-Dimethyldoxorubicin 是一种阿霉素 (Doxorubicin (HY-15142A)) 类似物。N,N-Dimethyldoxorubicin 对一一系列肿瘤细胞系具有细胞毒性 (IC50s < 0.3 μM)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Wander DPA, et al. Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs. J Org Chem. 2021 Apr 16;86(8):5757-5770.

N,N-dimethyldoxorubicin物理化学性质

• 分子式: C₂₉H₃₃NO₁₁
• 分子量: 571.57200
• 精确质量: 571.20500
• PSA: 183.29000
• LogP: 0.60420
• InChIKey: DJEFXYVVRUAFEB-SXPDSNDQSA-N
• SMILES: COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)CC(O)(C(=O)CO)CC3OC1CC(N(C)C)C(O)C(C)O1

N,N-dimethyldoxorubicin靶点实验

查看更多实验

实验名称：Cytotoxicity against human K562 cells at 10 uM incubated for 2 hrs followed by compou... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5554472

实验名称：Effect of chromatin damage activity in human MEL-JUSO cells stably expressing PAGFPH2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364538

实验名称：Induction of DNA damage in human K562 cells assessed as increase in gammaH2AX at 1 to... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5364536

实验名称：Induction of DNA damage in human K562 cells assessed as DNA double strand break measu... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5364537

实验名称：Cytotoxicity in human DU-145 cells assessed as reduction in cell viability incubated ... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL4687827

实验名称：Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viabilit... 来源：ChEMBL 靶标：U2OS External Id：CHEMBL5364534

实验名称：Cytotoxicity in human PC-3 cells assessed as reduction in cell viability incubated fo... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4687826

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：Induction of DNA damage in human K562 cells assessed as increase in gammaH2AX at 10 u... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5364535

实验名称：Drug uptake in human K562 cells at 1 uM by flow cytometry relative to doxorubicin 来源：ChEMBL 靶标：N/A External Id：CHEMBL4687829

共23条，当前第1页，共3页

1

2

3

N,N-dimethyldoxorubicin英文别名

• (8S,10S)-10-((2R,4S,5S,6S)-4-Dimethylamino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxy-acetyl)-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione