SIRT5 inhibitor 4

• 常用名: SIRT5 inhibitor 4
• 英文名: SIRT5 inhibitor 4
• CAS号: 708992-34-1
• 分子量: 369.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₅N₃O₄S
• 熔点: N/A
• 闪点: N/A

SIRT5 inhibitor 4用途

SIRT5抑制剂4(化合物11)是一种有效、选择性的SIRT5抑制物,SIRT5和其他SIRT亚型的IC50值分别为26.4和>400μM[1]。

SIRT5 inhibitor 4名称

• 英文名: SIRT5 inhibitor 4

SIRT5 inhibitor 4生物活性

• 描述: SIRT5抑制剂4(化合物11)是一种有效、选择性的SIRT5抑制物,SIRT5和其他SIRT亚型的IC50值分别为26.4和>400μM[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 靶点实验:

  SIRT5:26.4 μM (IC50)

  SIRT1:＞400 μM (IC50)

  SIRT2:＞400 μM (IC50)

  SIRT3:＞400 μM (IC50)

  SIRT6:＞400 μM (IC50)

  SIRT7:＞400 μM (IC50)

• 体外研究: SIRT5抑制剂4(化合物11)(6-200µM)以剂量依赖性方式稳定SIRT5蛋白,其温度漂移为1.8℃[1]。
• 参考文献:

  [1]. Han LY, et, al. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors. Eur.J.Med.Chem.2022 Jul 22, 114623

SIRT5 inhibitor 4物理化学性质

• 分子式: C₁₈H₁₅N₃O₄S
• 分子量: 369.39

SIRT5 inhibitor 4靶点实验

查看更多实验

实验名称：Inhibition of human SIRT1 using fluorogenic substrate at 400 uM preincubated for 1 hr... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL5109746

实验名称：Inhibition of human SIRT2 using fluorogenic substrate at 400 uM preincubated for 1 hr... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL5109747

实验名称：Inhibition of human SIRT3 using fluorogenic substrate at 400 uM preincubated for 1 hr... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL5109748

实验名称：Inhibition of human SIRT5 using fluorogenic substrate preincubated for 1 hr in presen... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5109743

实验名称：Stabilization of human SIRT5 assessed as change in melting temperature at 100 uM by t... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5109744

实验名称：Stabilization of wild type human SIRT5 assessed as melting temperature at 100 uM by t... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5109745

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