N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine

• 常用名: N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine
• 英文名: N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine
• CAS号: 722505-71-7
• 分子量: 425.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₈F₃N₅O₄
• 熔点: N/A
• 闪点: N/A

用途

N-[[4-(三氟甲基)苯基]甲基]腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

名称

• 英文名: N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine

生物活性

• 描述: N-[[4-(三氟甲基)苯基]甲基]腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

  [2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

物理化学性质

• 分子式: C₁₈H₁₈F₃N₅O₄
• 分子量: 425.36
• InChIKey: SGEXQCXUFHPEJQ-LSCFUAHRSA-N
• SMILES: OCC1OC(n2cnc3c(NCc4ccc(C(F)(F)F)cc4)ncnc32)C(O)C1O

靶点实验

查看更多实验

实验名称：Cytotoxicity against African green monkey Vero cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5523862

实验名称：Cytotoxicity against porcine PEK cells assessed as reduction in cell viability after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5523861

实验名称：Cytokinin activity in Amaranthus cotyledons assessed as dark induction of betacyanin ... 来源：ChEMBL 靶标：Amaranthus External Id：CHEMBL905598

实验名称：Antiviral activity against WNV infected in African green monkey Vero cells assessed a... 来源：ChEMBL 靶标：West Nile virus External Id：CHEMBL5523860

实验名称：Antiviral activity against YFV infected in African green monkey Vero cells assessed a... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL5523859

实验名称：Antiviral activity against TBEV infected in porcine PEK cells assessed as reduction i... 来源：ChEMBL 靶标：Tick-borne encephalitis virus External Id：CHEMBL5523858

实验名称：Cytokinin activity in wheat assessed as retention of chlorophyll in excised wheat lea... 来源：ChEMBL 靶标：Triticum aestivum External Id：CHEMBL905600

实验名称：Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL905611

实验名称：Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay 来源：ChEMBL 靶标：G-361 External Id：CHEMBL904600

实验名称：Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay 来源：ChEMBL 靶标：B16 External Id：CHEMBL904601

共16条，当前第1页，共2页

1

2