茶痂衣酸

• 常用名: 茶痂衣酸
• 英文名: Psoromic Acid
• CAS号: 7299-11-8
• 分子量: 358.30
• 密度: 1.483 g/cm3
• 沸点: 641.7ºC at 760 mmHg
• 分子式: C₁₈H₁₄O₈
• 熔点: N/A
• 闪点: 237ºC

茶痂衣酸用途

Psoromic acid是一种强效和选择性的RabGGTase(Rab香叶基-香叶基转移酶)抑制剂,IC50值为1.3µM。Psoromic acid是一种抗氧化剂。Psoromic acid表现出竞争型HMGR抑制和混合型ACE(血管紧张素转换酶)抑制[1][2]。

茶痂衣酸名称

• 中文名: 茶痂衣酸
• 英文名: 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid

茶痂衣酸生物活性

• 描述: Psoromic acid是一种强效和选择性的RabGGTase(Rab香叶基-香叶基转移酶)抑制剂,IC50值为1.3µM。Psoromic acid是一种抗氧化剂。Psoromic acid表现出竞争型HMGR抑制和混合型ACE(血管紧张素转换酶)抑制[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 1.3 µM (RabGGTase)[1]

• 参考文献:

  [1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91.

  [2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79.

茶痂衣酸物理化学性质

• 密度: 1.483 g/cm3
• 沸点: 641.7ºC at 760 mmHg
• 分子式: C₁₈H₁₄O₈
• 分子量: 358.30
• 闪点: 237ºC
• 精确质量: 358.06900
• PSA: 119.36000
• LogP: 2.85320
• InChIKey: FUCWJKJZOHOLEO-UHFFFAOYSA-N
• SMILES: COc1cc(C(=O)O)c2c(c1C)OC(=O)c1c(C)cc(O)c(C=O)c1O2
• 折射率: 1.658

茶痂衣酸毒性和生态

茶痂衣酸靶点实验

查看更多实验

实验名称：Toxicity against neonate larval stage of Spodoptera littoralis fed with diet containi... 来源：ChEMBL 靶标：Spodoptera littoralis External Id：CHEMBL3057995

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in expe... 来源：ChEMBL 靶标：Integrase External Id：CHEMBL697789

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in expe... 来源：ChEMBL 靶标：Integrase External Id：CHEMBL701792

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Inhibitory concentration of compound against strand transfer of HIV-1 integrase in ex... 来源：ChEMBL 靶标：Integrase External Id：CHEMBL699508

实验名称：Change in pupal weight of Spodoptera littoralis fed with diet containing compound at ... 来源：ChEMBL 靶标：Spodoptera littoralis External Id：CHEMBL3057474

共132条，当前第1页，共14页

1

2

3

4

5

茶痂衣酸英文别名

• Parellic acid
• Psoromsaeure
• psoromic acid