7299-11-8

• 常用中文名：茶痂衣酸
• 常用英文名：Psoromic Acid
• CAS号：7299-11-8
• 分子式：C₁₈H₁₄O₈
• 分子量：358.30
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-08-29 10:39:37
• 更新时间：2024-01-02 22:33:40
• Psoromic acid是一种强效和选择性的RabGGTase(Rab香叶基-香叶基转移酶)抑制剂,IC50值为1.3µM。Psoromic acid是一种抗氧化剂。Psoromic acid表现出竞争型HMGR抑制和混合型ACE(血管紧张素转换酶)抑制[1][2]。

名称

• 中文名: 茶痂衣酸
• 英文名: 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
• 英文别名: Parellic acid; Psoromsaeure; psoromic acid

物化性质

• 密度: 1.483 g/cm3
• 沸点: 641.7ºC at 760 mmHg
• 分子式: C₁₈H₁₄O₈
• 分子量: 358.30
• 闪点: 237ºC
• 精确质量: 358.06900
• PSA: 119.36000
• LogP: 2.85320
• 折射率: 1.658

生物活性

• 描述: Psoromic acid是一种强效和选择性的RabGGTase(Rab香叶基-香叶基转移酶)抑制剂,IC50值为1.3µM。Psoromic acid是一种抗氧化剂。Psoromic acid表现出竞争型HMGR抑制和混合型ACE(血管紧张素转换酶)抑制[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点:

  IC50: 1.3 µM (RabGGTase)[1]

• 参考文献:

  [1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91.

  [2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HP3082200 CHEMICAL NAME : 11H-Dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl- 11-oxo- CAS REGISTRY NUMBER : 7299-11-8 LAST UPDATED : 198308 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982

合成路线

60441-77-2 ~% 7299-11-8

文献：Shanghai Institute of Materia Medica, Chinese Academy of Sciences Patent: EP2199295 A1, 2010 ; Location in patent: Page/Page column 18 ;

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