厄弗酚

• 常用名: 厄弗酚
• 英文名: Effusol
• CAS号: 73166-28-6
• 分子量: 252.30800
• 密度: 1.229g/cm3
• 沸点: 508.9ºC at 760 mmHg
• 分子式: C₁₇H₁₆O₂
• 熔点: N/A
• 闪点: 248.4ºC

厄弗酚用途

Effusol 时可从Juncus effuses 中分离得到的一种酚类物质,对 DPPH 和 ABTS 自由基具有较强的清除活性,其IC50 值分别为 79 μM 和 2.73 μM。Effusol挽救皮质酮减弱的 CA1 LTP,保护海马功能对抗应激诱导的认知能力下降。

厄弗酚名称

• 中文名: 厄弗酚
• 英文名: 5-ethenyl-1-methyl-9,10-dihydrophenanthrene-2,7-diol

厄弗酚生物活性

• 描述: Effusol 时可从Juncus effuses 中分离得到的一种酚类物质,对 DPPH 和 ABTS 自由基具有较强的清除活性,其IC50 值分别为 79 μM 和 2.73 μM。Effusol挽救皮质酮减弱的 CA1 LTP,保护海马功能对抗应激诱导的认知能力下降。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kim, Ye Jin, et al. Antioxidant and Cytotoxic Activity of Compounds from the Stem of Juncus effuses. Journal of Applied Biological Chemistry. Volume 57 Issue 1 / Pages.47-51 / 2014 / 1976-0442(pISSN).

  [2]. Haruna Tamano, et al. CA1 LTP Attenuated by Corticosterone Is Canceled by Effusol via Rescuing Intracellular Zn 2+ Dysregulation. Cell Mol Neurobiol. 2019 Oct;39(7):975-983.

厄弗酚物理化学性质

• 密度: 1.229g/cm3
• 沸点: 508.9ºC at 760 mmHg
• 分子式: C₁₇H₁₆O₂
• 分子量: 252.30800
• 闪点: 248.4ºC
• 精确质量: 252.11500
• PSA: 40.46000
• LogP: 3.81480
• InChIKey: GEXAPRXWKRZPCK-UHFFFAOYSA-N
• SMILES: C=Cc1cc(O)cc2c1-c1ccc(O)c(C)c1CC2
• 外观性状: 黄色粉末
• 折射率: 1.684
• 储存条件: 室温，密封，通风

厄弗酚靶点实验

查看更多实验

实验名称：Ratio of MIC for methicillin-sensitive Staphylococcus aureus in dark to MIC for methi... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4002872

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induce... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5244463

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by m... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL1942014

实验名称：Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as reduction i... 来源：ChEMBL 靶标：Solute carrier family 22 member 6 External Id：CHEMBL4482185

实验名称：Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as reduction i... 来源：ChEMBL 靶标：Solute carrier family 22 member 6 External Id：CHEMBL4482187

实验名称：Ratio of MIC for methicillin-resistant Staphylococcus aureus in dark to MIC for methi... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4002873

实验名称：Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction i... 来源：ChEMBL 靶标：Solute carrier family 22 member 8 External Id：CHEMBL4482186

实验名称：Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction i... 来源：ChEMBL 靶标：Solute carrier family 22 member 8 External Id：CHEMBL4482188

实验名称：Binding affinity to ERalpha 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL865582

实验名称：Binding affinity to ERbeta 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL865583

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厄弗酚英文别名

• effusol