3'-表叠氮基3'-脱氧胸苷

• 常用名: 3'-表叠氮基3'-脱氧胸苷
• 英文名: 1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
• CAS号: 73971-82-1
• 分子量: 267.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₃N₅O₄
• 熔点: N/A
• 闪点: N/A

3'-表叠氮基3'-脱氧胸苷用途

3-表叠氮基-3-脱氧胸苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

3'-表叠氮基3'-脱氧胸苷名称

• 中文名: 3'-表叠氮基3'-脱氧胸苷
• 英文名: 3'-Azido-2',3'-dideoxy-3,4-dihydrothymidine

3'-表叠氮基3'-脱氧胸苷生物活性

• 描述: 3-表叠氮基-3-脱氧胸苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

3'-表叠氮基3'-脱氧胸苷物理化学性质

• 分子式: C₁₀H₁₃N₅O₄
• 分子量: 267.24
• 精确质量: 267.09700
• PSA: 134.33000
• InChIKey: HBOMLICNUCNMMY-BWZBUEFSSA-N
• SMILES: Cc1cn(C2CC(N=[N+]=[N-])C(CO)O2)c(=O)[nH]c1=O

3'-表叠氮基3'-脱氧胸苷靶点实验

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实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

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实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

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3'-表叠氮基3'-脱氧胸苷英文别名

• 5'OHCH2alloAZT
• 3'-azido-3'-deoxythymidine