咯萘啶

• 常用名: 咯萘啶
• 英文名: Pyronaridine
• CAS号: 74847-35-1
• 分子量: 518.050
• 密度: 1.4±0.1 g/cm3
• 沸点: 621.3±55.0 °C at 760 mmHg
• 分子式: C₂₉H₃₂ClN₅O₂
• 熔点: N/A
• 闪点: 329.6±31.5 °C

咯萘啶用途

吡啶是一种口服活性曼尼希碱抗疟剂。吡咯那定对恶性疟原虫和细粒棘球蚴感染有活性[1][2]。

咯萘啶名称

• 中文名: 磷酸咯萘啶
• 英文名: 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one

咯萘啶生物活性

• 描述: 吡啶是一种口服活性曼尼希碱抗疟剂。吡咯那定对恶性疟原虫和细粒棘球蚴感染有活性[1][2]。
• 相关类别:
  研究领域 >> 感染
• 体外研究: 吡啶(24小时)显示抗P。其IC50值为1.53-3.94nM[1]。
• 体内研究: 吡咯那定(57 mg/kg,口服,每日一次,持续30天)降低了细粒棘球蚴感染小鼠的寄生虫负担[2]。吡啶(57 mg/kg,腹腔注射,每日一次,持续3天)降低了二次感染(囊肿)小鼠的寄生虫负担[2]。在雄性ICR小鼠中,吡啶(57 mg/kg,腹腔注射,单剂量)在肝脏中的暴露量高于血浆中的暴露[2]。动物模型：细粒棘球蚴感染小鼠模型[2]剂量：57 mg/kg给药：口服,每日一次,持续30天结果：减少了42.4%的寄生虫湿重,杀死了90.7%的细粒棘球蚴二次感染(囊肿)。

咯萘啶物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 621.3±55.0 °C at 760 mmHg
• 分子式: C₂₉H₃₂ClN₅O₂
• 分子量: 518.050
• 闪点: 329.6±31.5 °C
• 精确质量: 517.224426
• PSA: 76.72000
• LogP: 4.80
• InChIKey: DJUFPMUQJKWIJB-UHFFFAOYSA-N
• SMILES: COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1
• 外观性状: 固体
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.720
• 储存条件: -20℃

咯萘啶靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：In vitro therapeutic index value is the ratio between IC50 values of [J] and [P] 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL838923

实验名称：Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2439161

实验名称：Antimalarial activity against early (1 to 3) gametocytic stage of Plasmodium falcipar... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2439659

实验名称：Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparu... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2439657

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

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咯萘啶英文别名

• 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
• C29H32ClN5O2
• 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
• Benzonaphthyridine 7351
• Malaridine
• pyronaridine phosphate salt
• Pyronaridine
• UNII-TD3P7Q3SG6
• 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol