6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

• 常用名: 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
• 英文名: 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
• CAS号: 752243-39-3
• 分子量: 307.346
• 密度: 1.4±0.1 g/cm3
• 沸点: 685.1±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 熔点: N/A
• 闪点: 368.2±28.7 °C

名称

• 英文名: 6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 685.1±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₃O₂
• 分子量: 307.346
• 闪点: 368.2±28.7 °C
• 精确质量: 307.132080
• PSA: 67.15000
• LogP: -0.13
• InChIKey: OZPFIJIOIVJZMN-GOSISDBHSA-N
• SMILES: CNC(=O)c1ccc2cc(C3(O)CCn4cncc43)ccc2c1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.695

靶点实验

查看更多实验

实验名称：Inhibition of 17,20-lyase of recombinant human CYP17A1 using [1,2-3H]-17a-hydroxypreg... 来源：ChEMBL 靶标：Steroid 17-alpha-hydroxylase/17,20 lyase External Id：CHEMBL1926383

实验名称：Inhibition of 17,20-lyase activity of Sprague-Dawley rat testicular microsomal CYP17A... 来源：ChEMBL 靶标：Steroid 17-alpha-hydroxylase/17,20 lyase External Id：CHEMBL1926382

实验名称：Inhibition of Sprague-Dawley rat adrenal gland 11-hydroxylase using [1,2-3H]-hydroxy-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1926385

实验名称：Inhibition of recombinant human CYP3A4 assessed as conversion of testosterone into 6-... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL1926384

实验名称：Binding affinity to C-terminal 6-His-tagged human CYP17A1 expressed in Escherichia co... 来源：ChEMBL 靶标：Steroid 17-alpha-hydroxylase/17,20 lyase External Id：CHEMBL4605329

实验名称：Reduction of serum testosterone level in cynomolgus monkey at 1 mg/kg, po after 8 hrs... 来源：ChEMBL 靶标：Macaca fascicularis External Id：CHEMBL1926387

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Reduction of serum DHEA level in cynomolgus monkey at 1 mg/kg, po after 8 hrs by radi... 来源：ChEMBL 靶标：Macaca fascicularis External Id：CHEMBL1926389

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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英文别名

• 6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
• UNII-267WB8R4TI
• TAK700
• CS-0611
• Orteronel,(R)
• TAK-700 R-form
• (R)-(-)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide