VU0134992

• 常用名: VU0134992
• 英文名: VU 0134992
• CAS号: 755002-90-5
• 分子量: 411.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₃₁BrN₂O₂
• 熔点: N/A
• 闪点: N/A

VU0134992用途

VU0134992 是一种选择性的内向整流钾通道 Kir4.1 阻滞剂,IC50 值为 0.97 μM。

VU0134992名称

• 中文名: VU0134992
• 英文名: VU0134992

VU0134992生物活性

• 描述: VU0134992 是一种选择性的内向整流钾通道 Kir4.1 阻滞剂,IC50 值为 0.97 μM。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  IC50: 0.97 µM (Kir4.1)[1]

• 体外研究: 对Kir4.1而言,VU0134992对Kir4.1的选择性大于30倍,Kir2.1和Kir2.2对Kir2.3,Kir6.2/SUR1和Kir7.1具有弱活性,并且同样对Kir3.1/3.2,Kir3.1/3.4和Kir4.2 [1]。
• 参考文献:

  [1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.

VU0134992物理化学性质

• 分子式: C₂₀H₃₁BrN₂O₂
• 分子量: 411.38
• InChIKey: OTTDLWFVHQYRDA-UHFFFAOYSA-N
• SMILES: CC(C)c1ccc(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)c(Br)c1
• 储存条件: -20°C，密封，干燥

VU0134992靶点实验

查看更多实验

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