ADTL-SA1215

• 常用名: ADTL-SA1215
• 英文名: ADTL-SA1215
• CAS号: 782387-91-1
• 分子量: 657.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₉I₂NO₃
• 熔点: N/A
• 闪点: N/A

ADTL-SA1215用途

ADTL-SA1215是一流的SIRT3特异性小分子激活剂,在三阴性乳腺癌中调节自噬。

ADTL-SA1215名称

• 英文名: ADTL-SA1215

ADTL-SA1215生物活性

• 描述: ADTL-SA1215是一流的SIRT3特异性小分子激活剂,在三阴性乳腺癌中调节自噬。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 参考文献:

  [1]. Zhang J, et al. Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer. J Med Chem. 2021 Oct 14;64(19):14192-14216.

ADTL-SA1215物理化学性质

• 分子式: C₂₆H₂₉I₂NO₃
• 分子量: 657.32
• InChIKey: NKCYHTOLLMRNJO-UHFFFAOYSA-N
• SMILES: CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCCN2CCCC2)c(I)c1

ADTL-SA1215靶点实验

查看更多实验

实验名称：Binding affinity to human SIRT5 human MDA-MB-231 cells assessed as increase in therma... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL4839966

实验名称：Binding affinity to human SIRT2 human MDA-MB-231 cells assessed as increase in therma... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL4839965

实验名称：Binding affinity to human SIRT1 human MDA-MB-231 cells assessed as increase in therma... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL4839964

实验名称：Binding affinity to human SIRT3 human MDA-MB-231 cells assessed as increase in therma... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL4839963

实验名称：Activation of SIRT3 in human MDA-MB-231 cell lysate assessed as decrease in acetylati... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL4839970

实验名称：Activation of SIRT3 in human MDA-MB-231 cell lysate assessed as decrease in acetylati... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL4839969

实验名称：Activation of SIRT3 in human MDA-MB-231 cell lysate assessed as decrease in acetylati... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL4839968

实验名称：Activation of SIRT3 in human MDA-MB-231 cell lysate assessed as decrease in acetylati... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL4839967

实验名称：Modulation of SIRT2 expression in human MDA-MB-231 cells up to 10 uM by Western blot ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4839958

实验名称：Modulation of SIRT1 expression in human MDA-MB-231 cells up to 10 uM by Western blot ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4839957

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