阿必鲁泰

更新时间：2025-08-23 21:31:19

阿必鲁泰结构式	常用名	阿必鲁泰	英文名	Albiglutide
	CAS号	782500-75-8	分子量	3283.603
	密度	1.5±0.1 g/cm3	沸点	N/A
	分子式	C₁₄₈H₂₂₄N₄₀O₄₅	熔点	N/A
	MSDS	N/A	闪点	N/A

阿必鲁泰用途

阿比鲁肽是一种胰高血糖素样肽-1(GLP-1)模拟物,是一种长效GLP-2受体激动剂。阿比鲁肽显著降低糖化血红蛋白(A1C)。阿比鲁肽可用于2型糖尿病(T2D)研究。阿比鲁肽是由抗DPP-4的GLP-1二聚体与人白蛋白的遗传融合产生的[1][2][3]。

中文名	阿必鲁泰
英文名	Albiglutide
英文别名	更多

描述	阿比鲁肽是一种胰高血糖素样肽-1(GLP-1)模拟物,是一种长效GLP-2受体激动剂。阿比鲁肽显著降低糖化血红蛋白(A1C)。阿比鲁肽可用于2型糖尿病(T2D)研究。阿比鲁肽是由抗DPP-4的GLP-1二聚体与人白蛋白的遗传融合产生的[1][2][3]。
相关类别	研究领域 >> 代谢疾病
参考文献	[1]. Matthews JE, et al. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008 Dec;93(12):4810-7. [2]. Blair HA, et al. Albiglutide: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2015 Apr;75(6):651-63. [3]. Trujillo JM, et al. Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Ann Pharmacother. 2014 Nov;48(11):1494-501.

描述

相关类别

研究领域 >> 代谢疾病

参考文献

[1]. Matthews JE, et al. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008 Dec;93(12):4810-7.

[2]. Blair HA, et al. Albiglutide: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2015 Apr;75(6):651-63.

[3]. Trujillo JM, et al. Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Ann Pharmacother. 2014 Nov;48(11):1494-501.

密度	1.5±0.1 g/cm3
分子式	C₁₄₈H₂₂₄N₄₀O₄₅
分子量	3283.603
精确质量	3281.646973
LogP	-5.20
InChIKey	JYDZPPZAYQTOIV-OTSUTHPESA-N
SMILES	CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=N)N)C(N)=O)C(C)C
外观性状	粉末
折射率	1.661
储存条件	-20℃

Gsk 716155

7-36-Glucagon-like peptide I (8-glycine) (human), fusion protein with 7-36-glucagon-like peptide I (8-glycine) (human) fusion protein with serum

Albugon

Naliglutide

Unii-5E7U48495e

7-36-Glucagon-likepeptide I [8-glycine] (huMan), fusion protein with 7-36-glucagon-like peptide I[8-glycine] (huMan) fusion protein with seruM albuMin (huMan)

L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L -lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide