2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine

• 常用名: 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine
• 英文名: 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine
• CAS号: 78636-53-0
• 分子量: 259.23
• 密度: 1.73 g/cm3
• 沸点: 495.4ºC at 760 mmHg
• 分子式: C₁₀H₁₄FN₃O₄
• 熔点: N/A
• 闪点: 253.4ºC

用途

2′-脱氧-2′-氟-5-甲基阿糖胞苷是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。

名称

• 英文名: 2'-fluoro-5-methylarabino-furanosylcytosine

生物活性

• 描述: 2′-脱氧-2′-氟-5-甲基阿糖胞苷是胞苷核苷类似物。胞苷类似物具有抑制DNA甲基转移酶的机制(如Zebularine,HY-13420),并具有潜在的抗代谢和抗肿瘤活性[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

物理化学性质

• 密度: 1.73 g/cm3
• 沸点: 495.4ºC at 760 mmHg
• 分子式: C₁₀H₁₄FN₃O₄
• 分子量: 259.23
• 闪点: 253.4ºC
• 精确质量: 275.09200
• PSA: 127.70000
• InChIKey: QZZJZXAWLQYJFK-JVZYCSMKSA-N
• SMILES: Cc1cn(C2OC(CO)C(O)C2F)c(=O)nc1N
• 折射率: 1.674

靶点实验

查看更多实验

实验名称：Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate MJ3 infec... 来源：ChEMBL 靶标：Macacine alphaherpesvirus 1 External Id：CHEMBL1220399

实验名称：Antiherpetic activity against HSV-2 来源：ChEMBL 靶标：Human alphaherpesvirus 2 External Id：CHEMBL694610

实验名称：Ratio of acyclovir EC50 to compound EC50 for HSV1 infected in african green monkey Ve... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL1220397

实验名称：Ratio of acyclovir EC50 to compound EC50 for HSV 2 infected in african green monkey V... 来源：ChEMBL 靶标：Human alphaherpesvirus 2 External Id：CHEMBL1220396

实验名称：Ratio of ID50/ID90 in HSV-1 in fected cells 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL850433

实验名称：Antiherpetic activity against HSV-1 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL883993

实验名称：Ratio of ID50/ID90 in HSV-2 infected cells 来源：ChEMBL 靶标：Human alphaherpesvirus 2 External Id：CHEMBL850437

实验名称：Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate A4 infect... 来源：ChEMBL 靶标：Macacine alphaherpesvirus 1 External Id：CHEMBL1220407

实验名称：Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate A5 infect... 来源：ChEMBL 靶标：Macacine alphaherpesvirus 1 External Id：CHEMBL1220406

实验名称：Cytotoxic activity against vero cells was evaluated. 来源：ChEMBL 靶标：Vero External Id：CHEMBL821164

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英文别名

• 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-ethyl