2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine
2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine structure
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Common Name | 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine | ||
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| CAS Number | 78636-53-0 | Molecular Weight | 259.23 | |
| Density | 1.73 g/cm3 | Boiling Point | 495.4ºC at 760 mmHg | |
| Molecular Formula | C10H14FN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 253.4ºC | |
Use of 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. |
Summary: 4-Amino-1-(2-deoxy-2-fluoro-BETA-D-arabinofuranosyl)-5-methyl-2(1H)-pyrimidone (Chinese name), also known as 2'-fluoro-5-methylarabino-furanosylcytosine, with CAS number 78636-53-0, has a molecular formula of C10H14FN3O4 and a molecular weight of 259.23. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2'-fluoro-5-methylarabino-furanosylcytosine |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.73 g/cm3 |
|---|---|
| Boiling Point | 495.4ºC at 760 mmHg |
| Molecular Formula | C10H14FN3O4 |
| Molecular Weight | 259.23 |
| Flash Point | 253.4ºC |
| Exact Mass | 275.09200 |
| PSA | 127.70000 |
| Index of Refraction | 1.674 |
| InChIKey | QZZJZXAWLQYJFK-JVZYCSMKSA-N |
| SMILES | Cc1cn(C2OC(CO)C(O)C2F)c(=O)nc1N |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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2′-Deoxy-2′-flu... CAS#:78636-53-0 |
| Literature: Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156 |
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~%
2′-Deoxy-2′-flu... CAS#:78636-53-0 |
| Literature: Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156 |
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~%
2′-Deoxy-2′-flu... CAS#:78636-53-0 |
| Literature: Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156 |
|
~%
2′-Deoxy-2′-flu... CAS#:78636-53-0 |
| Literature: Watanabe, Kyoichi A.; Su, Tsann-Long; Klein, Robert S.; Chu, Chung K.; Matsuda, Akira; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 152 - 156 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 1 | |
CAS#:69256-17-3This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate MJ3 infec...
Source: ChEMBL
Target: Macacine alphaherpesvirus 1
External Id: CHEMBL1220399
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Name: Antiherpetic activity against HSV-2
Source: ChEMBL
Target: Human alphaherpesvirus 2
External Id: CHEMBL694610
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Name: Ratio of acyclovir EC50 to compound EC50 for HSV1 infected in african green monkey Ve...
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL1220397
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Name: Ratio of acyclovir EC50 to compound EC50 for HSV 2 infected in african green monkey V...
Source: ChEMBL
Target: Human alphaherpesvirus 2
External Id: CHEMBL1220396
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Name: Ratio of ID50/ID90 in HSV-1 in fected cells
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL850433
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Name: Antiherpetic activity against HSV-1
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL883993
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Name: Ratio of ID50/ID90 in HSV-2 infected cells
Source: ChEMBL
Target: Human alphaherpesvirus 2
External Id: CHEMBL850437
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Name: Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate A4 infect...
Source: ChEMBL
Target: Macacine alphaherpesvirus 1
External Id: CHEMBL1220407
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Name: Ratio of acyclovir EC50 to compound EC50 for Macacine herpesvirus 1 isolate A5 infect...
Source: ChEMBL
Target: Macacine alphaherpesvirus 1
External Id: CHEMBL1220406
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Name: Cytotoxic activity against vero cells was evaluated.
Source: ChEMBL
Target: Vero
External Id: CHEMBL821164
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-ethyl |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does 2'-fluoro-5-methylarabino-furanosylcytosine have? |
| A: English synonyms of 2'-fluoro-5-methylarabino-furanosylcytosine: 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-ethyl. |
| Q: What is the molecular formula of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: Molecular formula of 2'-fluoro-5-methylarabino-furanosylcytosine is C10H14FN3O4. |
| Q: What is the Chinese name of 78636-53-0? |
| A: Chinese name of 78636-53-0 is 78636-53-0. |
| Q: What is the polar surface area (PSA) of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: Polar surface area (PSA) of 2'-fluoro-5-methylarabino-furanosylcytosine is 127.70000. |
| Q: What are the uses of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: Main uses of 2'-fluoro-5-methylarabino-furanosylcytosine: 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1]. |
| Q: What are the downstream products of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: Related downstream products(CAS) of 2'-fluoro-5-methylarabino-furanosylcytosine: 69256-17-3. |
| Q: What is the CAS number of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: CAS number of 2'-fluoro-5-methylarabino-furanosylcytosine is 78636-53-0. |
| Q: What is the English name of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: The English name of 2'-fluoro-5-methylarabino-furanosylcytosine is 2'-fluoro-5-methylarabino-furanosylcytosine. |
| Q: What is the InChIKey of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: InChIKey of 2'-fluoro-5-methylarabino-furanosylcytosine is QZZJZXAWLQYJFK-JVZYCSMKSA-N. |
| Q: What is the SMILES notation of 2'-fluoro-5-methylarabino-furanosylcytosine? |
| A: SMILES notation of 2'-fluoro-5-methylarabino-furanosylcytosine is Cc1cn(C2OC(CO)C(O)C2F)c(=O)nc1N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Dayang Chem (Hangzhou) Co., Ltd. |