rac 5-羟基丙戊酸钠盐

• 常用名: rac 5-羟基丙戊酸钠盐
• 英文名: rac 5-Hydroxy Valproic Acid Sodium Salt
• CAS号: 78644-53-8
• 分子量: 182.19
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₁₅NaO₃
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

rac 5-羟基丙戊酸钠盐用途

rac 5-羟基丙戊酸钠盐是5-羟基丙戊酸（一种丙戊酸的代谢物）的外消旋混合物。据报道，在丙戊酸向5-羟基丙戊酸的代谢中，CYP4B1可能在这种转化中起作用，如使用针对CYP4B1的单特异性多克隆抗体所证明的那样。丙戊酸是一种支链脂肪酸，据报道可以潜在地增强中枢GABA能神经传递并抑制Na | + |通道。目前，尚未完全阐明丙戊酸的各种分子作用机理。据报道，丙戊酸在体外是组蛋白脱乙酰基酶（HDACs）的有效抑制剂。还注意到丙戊酸可减轻HDAC依赖的转录抑制，并在培养的细胞中引起组蛋白的超乙酰化。在动物研究 rac 5-Hydroxy Valproic Acid Sodium Salt is a racemic mixture of 5-Hydroxy Valproic Acid, a metabolite of Valproic Acid. In the metabolism of Valproic Acid to 5-Hydroxy Valproic Acid, it has been reported that CYP4B1 may play a role in this conversion, as demonstrated using monospecific polyclonal antibodies directed against CYP4B1. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na|+|channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs)|in vitro|. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase.|Metabolites of Valproic Acid are also available as:|Valproic Acid |Valproic Acid, Sodium Salt |3-Hydroxy Valproic Acid |3-Keto Valproic Acid Sodium Salt |4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) |Valproic Acid β-D-Glucuronide Allyl Ester |Valproic Acid β-D-Glucuronide |Labelled forms of Valproic Acid are available as:|Valproic Acid-d6 |Valproic Acid-d6 β-D-Glucuronide |rac 5-Hydroxy Valproic Acid-d7 Sodium Salt

rac 5-羟基丙戊酸钠盐名称

• 中文名: rac 5-羟基丙戊酸钠盐
• 英文名: rac 5-Hydroxy Valproic Acid Sodium Salt

rac 5-羟基丙戊酸钠盐物理化学性质

• 分子式: C₈H₁₅NaO₃
• 分子量: 182.19
• 精确质量: 182.091888
• 储存条件: -20°C储存
• 水溶解性: Soluble in Methanol

rac 5-羟基丙戊酸钠盐安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
• 危险品运输编码: NONH for all modes of transport

rac 5-羟基丙戊酸钠盐英文别名

• 5-OH-VPA
• 5-Hydroxy-2-propylpentanoic Acid
• 2-Propyl-5-hydroxypentanoic Acid Sodium Salt