5-甲基-6-氧代-5,6-乙基二氢-4H-苯并[f]咪唑[1,5-a] [1,4]二氮杂-3-羧酸酯-d3乙酯

• 常用名: 5-甲基-6-氧代-5,6-乙基二氢-4H-苯并[f]咪唑[1,5-a] [1,4]二氮杂-3-羧酸酯-d3乙酯
• 英文名: Ro 14-7437
• CAS号: 78756-03-3
• 分子量: 285.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₅N₃O₃
• 熔点: N/A
• 闪点: N/A

用途

Ro 14-7437 是一种强效、选择性的 Midazolam 增强拮抗剂。

名称

• 中文名: 5-甲基-6-氧代-5,6-乙基二氢-4H-苯并[f]咪唑[1,5-a] [1,4]二氮杂-3-羧酸酯-d3乙酯
• 英文名: ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

生物活性

• 描述: Ro 14-7437 是一种强效、选择性的 Midazolam 增强拮抗剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Nistri A,et al. Potentiating action of midazolam on GABA-mediated responses and its antagonism by Ro 14-7437 in the frog spinal cord. Neurosci Lett. 1983 Aug 29;39(2):199-204.

物理化学性质

• 分子式: C₁₅H₁₅N₃O₃
• 分子量: 285.30
• 精确质量: 285.11100
• PSA: 64.43000
• LogP: 1.57250
• InChIKey: HNGRWUCKESPKRC-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1ncn2c1CN(C)C(=O)c1ccccc1-2

靶点实验

查看更多实验

实验名称：Displacement of [3H]flunitrazepam from diazepam-sensitive GABA-A benzodiazepine recep... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL650999

实验名称：GABA shift ratio at Diazepam sensitive fraction of GABA-A benzodiazepine receptor 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL841639

实验名称：Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-2 External Id：CHEMBL681248

实验名称：Ratio between diazepam-insensitive (DI) site / diazepam-sensitive (DS) site 来源：ChEMBL 靶标：N/A External Id：CHEMBL850400

实验名称：Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alph... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-6 External Id：CHEMBL683045

实验名称：Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor i... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL680655

实验名称：Binding affinity against Diazepam insensitive (DI) Gamma-aminobutyric acid A receptor 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL680654

实验名称：Ratio of binding affinity against DI Bz receptor to that of DS Bz receptor 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL851452

实验名称：Displacement of [3H]flunitrazepam from diazepam-insensitive GABA-A benzodiazepine rec... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL648132

实验名称：Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alph... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL681480

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英文别名

• ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][ 1,4]benzodiazepine-3-carboxylate
• Ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• Ethyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a) (1,4)-benzodiazepine-3-carboxylate
• 4H-Imidazo[1,5-a][1,4] benzodiazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, ethyl ester
• Ethyl 5-Methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate