Demethylasterriquinone B1

• 常用名: Demethylasterriquinone B1
• 英文名: Demethylasterriquinone B1
• CAS号: 78860-34-1
• 分子量: 506.59200
• 密度: 1.335g/cm3
• 沸点: 780.2ºC at 760 mmHg
• 分子式: C₃₂H₃₀N₂O₄
• 熔点: N/A
• 闪点: 425.6ºC

Demethylasterriquinone B1用途

去甲基菊醌B1是一种选择性胰岛素受体激活剂。去甲基菊醌B1刺激IRβ亚基的酪氨酸磷酸化,以及PIK3和AKT的激活[1]。

Demethylasterriquinone B1名称

• 英文名: 5-(7-but-2-enyl-1H-indol-3-yl)-3-hydroxy-2-(2-propan-2-yl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione

Demethylasterriquinone B1生物活性

• 描述: 去甲基菊醌B1是一种选择性胰岛素受体激活剂。去甲基菊醌B1刺激IRβ亚基的酪氨酸磷酸化,以及PIK3和AKT的激活[1]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
• 参考文献:

  [1]. Li M, et al. Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells. Diabetes. 2001;50(10):2323-2328.

Demethylasterriquinone B1物理化学性质

• 密度: 1.335g/cm3
• 沸点: 780.2ºC at 760 mmHg
• 分子式: C₃₂H₃₀N₂O₄
• 分子量: 506.59200
• 闪点: 425.6ºC
• 精确质量: 506.22100
• PSA: 106.18000
• LogP: 7.01170
• InChIKey: XMGNJVXBPZAETK-UHFFFAOYSA-N
• SMILES: C=CC(C)(C)c1[nH]c2ccccc2c1C1=C(O)C(=O)C(c2c[nH]c3c(CC=C(C)C)cccc23)=C(O)C1=O
• 折射率: 1.72

Demethylasterriquinone B1靶点实验

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实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Percent activation of insulin receptor in CHO cells by 10 uM of compound 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL697200

实验名称：Ability to activate the insulin receptor compared to that of lead structure 1 express... 来源：ChEMBL 靶标：Insulin receptor External Id：CHEMBL698974

实验名称：qHTS for inhibitors of Vif-A3G interactions: Validation 来源：NCGC 靶标：DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] External Id：VIFG001

实验名称：Confirmatory qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC 靶标：N/A External Id：APP-Toga-CHIKV-nsP2-f2-f9

实验名称：Selectivity profile for inhibitors of NSP2Pro chikungunya virus (CHIKV): Papain Count... 来源：NCGC External Id：APP-Toga-CHIKV-nsP2-f3_f16

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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Demethylasterriquinone B1英文别名

• Demethylasterriquinone B1