N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐

• 常用名: N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐
• 英文名: Calmodulin antagonist-1
• CAS号: 78957-84-3
• 分子量: 349.28
• 密度: N/A
• 沸点: 501.5ºC at 760 mmHg
• 分子式: C₁₄H₁₈Cl₂N₂O₂S
• 熔点: 243-246ºC
• 闪点: 257.1ºC

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐用途

钙调素拮抗剂-1(W-7)是一种钙调素(CaM)拮抗剂。钙调素拮抗剂-1抑制钙调素激活的钙-磷酸二酯酶(PDE)(IC50=28μM)。钙调素拮抗剂-1还以与环GMP竞争的方式抑制经胰蛋白酶处理的Ca2+-PDE(IC50=375μM),Ki值为300μM[1]。

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐名称

• 中文名: N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐
• 英文名: N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide,hydrochloride

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐生物活性

• 描述: 钙调素拮抗剂-1(W-7)是一种钙调素(CaM)拮抗剂。钙调素拮抗剂-1抑制钙调素激活的钙-磷酸二酯酶(PDE)(IC50=28μM)。钙调素拮抗剂-1还以与环GMP竞争的方式抑制经胰蛋白酶处理的Ca2+-PDE(IC50=375μM),Ki值为300μM[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 神经信号通路 >> 蛋白激酶
• 参考文献:

  [1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726.

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐物理化学性质

• 沸点: 501.5ºC at 760 mmHg
• 熔点: 243-246ºC
• 分子式: C₁₄H₁₈Cl₂N₂O₂S
• 分子量: 349.28
• 闪点: 257.1ºC
• 精确质量: 348.046600
• PSA: 80.57000
• LogP: 5.48440
• InChIKey: IKMXJMNRHREPOD-UHFFFAOYSA-N
• SMILES: Cl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
• 储存条件: -20°C，干燥，密封

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐安全信息

• 海关编码: 2935009090

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐海关

• 海关编码: 2935009090
• 中文概述: 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐英文别名

• 1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1)
• N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1)
• N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
• 4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride
• N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride
• OR0190T
• Calmodulin antagonist-1