AS8351

• 常用名: AS8351
• 英文名: AS 8351
• CAS号: 796-42-9
• 分子量: 291.30400
• 密度: 1.364g/cm3
• 沸点: 503.5ºC at 760 mmHg
• 分子式: C₁₇H₁₃N₃O₂
• 熔点: 266 °C
• 闪点: 258.3ºC

AS8351用途

AS8351 是一种 KDM5B 抑制剂,可以诱导和维持有活性的染色质标记从而促进心肌细胞样细胞的产生。

AS8351名称

• 中文名: AS8351
• 英文名: 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone

AS8351生物活性

• 描述: AS8351 是一种 KDM5B 抑制剂,可以诱导和维持有活性的染色质标记从而促进心肌细胞样细胞的产生。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
  研究领域 >> 心血管疾病
• 靶点实验:

  KDM5B[1]

• 体外研究: AS8351通过与α-酮戊二酸(α-KG)竞争某些表观遗传酶中的铁[Fe(II)],如需要α-KG和铁的含有JmjC结构域的组蛋白去甲基化酶(JmjC-KDMs),影响表观遗传修饰。作为辅因子[2]。
• 参考文献:

  [1]. Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23(8):893-916.

  [2]. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.

AS8351物理化学性质

• 密度: 1.364g/cm3
• 沸点: 503.5ºC at 760 mmHg
• 熔点: 266 °C
• 分子式: C₁₇H₁₃N₃O₂
• 分子量: 291.30400
• 闪点: 258.3ºC
• 精确质量: 291.10100
• PSA: 74.58000
• LogP: 3.09520
• InChIKey: WQSHHAVECQJKLX-UHFFFAOYSA-N
• SMILES: O=C(NN=Cc1c(O)ccc2ccccc12)c1ccncc1
• 外观性状: 固体;White to Orange to Green powder to crystaline
• 折射率: 1.715
• 储存条件: 0-10°C;存放于惰性气体之中;避免湿气 (吸湿),加热

AS8351安全信息

• 海关编码: 2933399090

AS8351海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

AS8351靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum... 来源：The Scripps Research Institute Molecular Screening Center 靶标：transactivating tegument protein VP16 [Human herpesvirus 1] External Id：VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based high throughput confirmation assay for inhibitors of th... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens] External Id：SRC1_INH_LUMI_1536_3X%INH CRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Confirmatory qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 ... 来源：NCGC External Id：epac1-activator-f1f2f3f4

实验名称：Confirmatory qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor... 来源：NCGC External Id：epac1-inhibitor-f1f2f3f4

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AS8351英文别名

• Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid]
• 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone
• 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone
• 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid
• isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide]
• 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine
• (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
• AS-8351
• AS8351