AS 8351
Modify Date: 2026-07-03 10:55:02
AS 8351 structure
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Common Name | AS 8351 | ||
|---|---|---|---|---|
| CAS Number | 796-42-9 | Molecular Weight | 291.30400 | |
| Density | 1.364g/cm3 | Boiling Point | 503.5ºC at 760 mmHg | |
| Molecular Formula | C17H13N3O2 | Melting Point | 266 °C | |
| MSDS | N/A | Flash Point | 258.3ºC | |
Use of AS 8351AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells. |
| Name | 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone |
|---|---|
| Synonym | More Synonyms |
| Description | AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells. |
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| Related Catalog | |
| Target |
KDM5B[1] |
| In Vitro | AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2]. |
| References |
| Density | 1.364g/cm3 |
|---|---|
| Boiling Point | 503.5ºC at 760 mmHg |
| Melting Point | 266 °C |
| Molecular Formula | C17H13N3O2 |
| Molecular Weight | 291.30400 |
| Flash Point | 258.3ºC |
| Exact Mass | 291.10100 |
| PSA | 74.58000 |
| LogP | 3.09520 |
| Index of Refraction | 1.715 |
| InChIKey | WQSHHAVECQJKLX-UHFFFAOYSA-N |
| SMILES | O=C(NN=Cc1c(O)ccc2ccccc12)c1ccncc1 |
| HS Code | 2933399090 |
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| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
Source: The Scripps Research Institute Molecular Screening Center
Target: transactivating tegument protein VP16 [Human herpesvirus 1]
External Id: VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Luminescence-based cell-based high throughput confirmation assay for inhibitors of th...
Source: The Scripps Research Institute Molecular Screening Center
Target: nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
External Id: SRC1_INH_LUMI_1536_3X%INH CRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: Confirmatory qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 ...
Source: NCGC
External Id: epac1-activator-f1f2f3f4
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Name: Confirmatory qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor...
Source: NCGC
External Id: epac1-inhibitor-f1f2f3f4
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| Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid] |
| 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone |
| 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone |
| 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid |
| isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide] |
| 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine |
| (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide |
| AS-8351 |
| AS8351 |