AS 8351
Modify Date: 2024-01-04 17:04:53
AS 8351 structure
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Common Name | AS 8351 | ||
|---|---|---|---|---|
| CAS Number | 796-42-9 | Molecular Weight | 291.30400 | |
| Density | 1.364g/cm3 | Boiling Point | 503.5ºC at 760 mmHg | |
| Molecular Formula | C17H13N3O2 | Melting Point | 266 °C | |
| MSDS | N/A | Flash Point | 258.3ºC | |
Use of AS 8351AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells. |
| Name | 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone |
|---|---|
| Synonym | More Synonyms |
| Description | AS8351 is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells. |
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| Related Catalog | |
| Target |
KDM5B[1] |
| In Vitro | AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors[2]. |
| References |
| Density | 1.364g/cm3 |
|---|---|
| Boiling Point | 503.5ºC at 760 mmHg |
| Melting Point | 266 °C |
| Molecular Formula | C17H13N3O2 |
| Molecular Weight | 291.30400 |
| Flash Point | 258.3ºC |
| Exact Mass | 291.10100 |
| PSA | 74.58000 |
| LogP | 3.09520 |
| Index of Refraction | 1.715 |
| HS Code | 2933399090 |
|---|
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Isonicotinsaeure-[(2-hydroxy-[1]naphthylmethylen)-hydrazid] |
| 2-hydroxy-1-napthaldehyde isonicotinoylhydrazone |
| 2-hydroxy-1-naphthyl aldehyde isonicotinoyl hydrazone |
| 1-Isonicotinoyl-5-(4-nitro-phenyl)-carbohydrazid |
| isonicotinic acid-[(2-hydroxy-[1]naphthylmethylene)-hydrazide] |
| 1-isonicotinyl-2-(2-hydroxy-1-naphthylidene) hydrazine |
| (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide |
| AS-8351 |
| AS8351 |