9-Carboxymethoxymethylguanine

• 常用名: 9-Carboxymethoxymethylguanine
• 英文名: 9-Carboxymethoxymethylguanine
• CAS号: 80685-22-9
• 分子量: 239.19
• 密度: 1.9±0.1 g/cm3
• 沸点: 696.5±63.0 °C at 760 mmHg
• 分子式: C₈H₉N₅O₄
• 熔点: N/A
• 闪点: 375.0±33.7 °C

9-Carboxymethoxymethylguanine用途

9-羧甲氧基甲基鸟嘌呤是阿昔洛韦的主要代谢产物。阿昔洛韦(阿昔洛韦)是一种鸟苷类似物和一种口服抗病毒药物[1]。

9-Carboxymethoxymethylguanine名称

• 英文名: 9-Carboxymethoxymethylguanine

9-Carboxymethoxymethylguanine生物活性

• 描述: 9-羧甲氧基甲基鸟嘌呤是阿昔洛韦的主要代谢产物。阿昔洛韦(阿昔洛韦)是一种鸟苷类似物和一种口服抗病毒药物[1]。
• 相关类别:
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
• 体外研究: 阿昔洛韦由乙醇脱氢酶(ADH)酶代谢为阿昔洛韦醛,阿昔洛韦醛随后由醛脱氢酶(ALDH)酶代谢为9-羧甲氧基甲基鸟嘌呤(CMMG)[1]。
• 参考文献:

  [1]. Patrina Gunness, et al. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301.

9-Carboxymethoxymethylguanine物理化学性质

• 密度: 1.9±0.1 g/cm3
• 沸点: 696.5±63.0 °C at 760 mmHg
• 分子式: C₈H₉N₅O₄
• 分子量: 239.19
• 闪点: 375.0±33.7 °C
• 精确质量: 239.065460
• LogP: -1.37
• InChIKey: MICNQLKUSOVNNG-UHFFFAOYSA-N
• SMILES: Nc1nc2c(ncn2COCC(=O)O)c(=O)[nH]1
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.802

9-Carboxymethoxymethylguanine靶点实验

查看更多实验

实验名称：AUC (0 to 12 hrs) in human CSF with chronic kidney disease assessed as CMMG level at ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266555

实验名称：Ratio of Cmax in human CSF to Cmax in human plasma with chronic kidney disease assess... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266571

实验名称：Ratio of Cmax in human CSF to Cmax in human plasma with normal renal function assesse... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266570

实验名称：AUC (0 to 12 hrs) in human systemic circulation with chronic kidney disease assessed ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266554

实验名称：AUC (0 to 6 hrs) in human CSF with normal renal function assessed as CMMG level at 20... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266553

实验名称：AUC (0 to 6 hrs) in human systemic circulation with normal renal function assessed as... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266552

实验名称：Tmax in human CSF with chronic kidney disease assessed as CMMG level at 1500 mg, po e... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266551

实验名称：Tmax in human systemic circulation with chronic kidney disease assessed as CMMG level... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266550

实验名称：Tmax in human CSF with normal renal function assessed as CMMG level at 2000 mg, po ev... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266549

实验名称：Tmax in human systemic circulation with normal renal function assessed as CMMG level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL1266548

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9-Carboxymethoxymethylguanine英文别名

• N28227W35C
• [(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]acetic acid
• CMMG
• 9-Carboxymethoxymethylguanine