脱氧皮质酮新戊酸酯

• 常用名: 脱氧皮质酮新戊酸酯
• 英文名: Desoxycorticosterone pivalate
• CAS号: 808-48-0
• 分子量: 414.57800
• 密度: 1.111 g/cm3
• 沸点: 529.012ºC at 760 mmHg
• 分子式: C₂₆H₃₈O₄
• 熔点: 198-204ºC
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

脱氧皮质酮新戊酸酯用途

Desoxycorticosterone pivalate (DOCP) 是一种盐皮质激素,是地塞米松的类似物。Desoxycorticosterone pivalate 用于治疗犬肾上腺皮质功能减退症。

脱氧皮质酮新戊酸酯名称

• 中文名: 去氧皮质酮新戊酸酯
• 英文名: 11-deoxycorticosterone pivalate
• 中文别名: 孕甾-4-烯-3,20-二酮,21-(2,2-二甲基-1-丙酸)酯 | 特戊酸去氧皮质酮

脱氧皮质酮新戊酸酯生物活性

• 描述: Desoxycorticosterone pivalate (DOCP) 是一种盐皮质激素,是地塞米松的类似物。Desoxycorticosterone pivalate 用于治疗犬肾上腺皮质功能减退症。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 体内研究: 开始剂量为1.5毫克/千克去氧皮质酮丙戊酸钠(DOCP)可有效控制大多数PH犬的临床症状和血清电解质浓度。通常需要额外减少剂量以维持28-30天的注射间隔。幼小和生长的动物似乎需要更高的剂量[1]。
• 参考文献:

  [1]. Sieber-Ruckstuhl NS, et al. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. J Vet Intern Med. 2019 May;33(3):1266-1271.

  [2]. Masticatory Muscle Myositis: Pathogenesis, Diagnosis, and Treatment.

脱氧皮质酮新戊酸酯物理化学性质

• 密度: 1.111 g/cm3
• 沸点: 529.012ºC at 760 mmHg
• 熔点: 198-204ºC
• 分子式: C₂₆H₃₈O₄
• 分子量: 414.57800
• 精确质量: 414.27700
• PSA: 60.44000
• LogP: 5.29290
• InChIKey: VVOIQBFMTVCINR-WWMZEODYSA-N
• SMILES: CC(C)(C)C(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
• 折射率: 1.534
• 储存条件: -20°C

脱氧皮质酮新戊酸酯毒性和生态

脱氧皮质酮新戊酸酯安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302 + H312 + H332
• 警示性声明: P261-P280-P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

脱氧皮质酮新戊酸酯靶点实验

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实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Antagonist activity at human CNR1 in an in vitro cell-based assay measured by fluores... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291772

实验名称：Agonist activity at human CNR1 in an in vitro cell-based assay measured by fluorescen... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291771

实验名称：Binding affinity towards human CNR1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291773

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脱氧皮质酮新戊酸酯英文别名

• 21-pivaloyloxy-pregn-4-ene-3,20-dione
• Desoxycorticosterone pivalate
• neodin-depositum
• MFCD00199992
• 21-Pivaloyloxy-pregn-4-en-3,20-dion
• Percorten pivalate
• deoxycorticosterone pivalate
• percortenm
• Desoxycortisone pivalate
• DOC PIVALATE
• docp
• cortexonem
• deoxycortonepivalate
• desoxycortone pivalate
• EINECS 212-366-0